Evidence map›Paper›PMID 31429679›Full record

ArticleRadiology2019

Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function Detected at Quantitative MRI.

Alessandra Caporale, Michael C Langham, Wensheng Guo, Alyssa Johncola, Shampa Chatterjee, Felix W Wehrli

Registry-linked trialOpen access · greenAbstract readEvaluation Study
In one paragraph

Article in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03479203 (Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity), which is not on this map. Cited by 76 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 4 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03479203 early_phase1completednot on this map

Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity

TypeinterventionalSponsorUniversity of PennsylvaniaRan2018 to 2022Enrolled31ConditionsEndothelial Dysfunction, Biochemical MarkersArmsElectronic Cigarette Aerosol
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 4 syntheses or guidelines pooled it, 126 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Review
  8. Article
  9. Review
  10. Investigating changes in vape use among Canadian youth from 2014 to 2022.Canadian journal of public health = Revue canadienne de sante publique · 2026
    Article
  11. Review
  12. Human Primary Mesenchymal Stem Cells Fail to Recover Full Osteogenic Differentiation Potential Following Washout of Electronic Cigarette Aerosol Extracts.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
  13. Review
  14. Toxicity and Appeal of Flavoured E-Cigarettes and Flavour Ban Outcomes: A Narrative Review.International journal of environmental research and public health · 2026
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alessandra CaporaleFrom the Laboratory for Structural, Physiologic and Functional Imaging, Department of Radiology (A.C., M.C.L., A.J., F.W.W.), Department of Biostatistics and Epidemiology (W.G.), and Institute for Environmental Medicine and Department of Physiology (S.C.), University of Pennsylvania Perelman School of Medicine, 3400 Spruce St, Philadelphia, PA 19104.ORCID 0000-0002-2182-8312
Michael C LanghamFrom the Laboratory for Structural, Physiologic and Functional Imaging, Department of Radiology (A.C., M.C.L., A.J., F.W.W.), Department of Biostatistics and Epidemiology (W.G.), and Institute for Environmental Medicine and Department of Physiology (S.C.), University of Pennsylvania Perelman School of Medicine, 3400 Spruce St, Philadelphia, PA 19104.ORCID 0000-0002-8733-1317
Wensheng GuoFrom the Laboratory for Structural, Physiologic and Functional Imaging, Department of Radiology (A.C., M.C.L., A.J., F.W.W.), Department of Biostatistics and Epidemiology (W.G.), and Institute for Environmental Medicine and Department of Physiology (S.C.), University of Pennsylvania Perelman School of Medicine, 3400 Spruce St, Philadelphia, PA 19104.
Alyssa JohncolaFrom the Laboratory for Structural, Physiologic and Functional Imaging, Department of Radiology (A.C., M.C.L., A.J., F.W.W.), Department of Biostatistics and Epidemiology (W.G.), and Institute for Environmental Medicine and Department of Physiology (S.C.), University of Pennsylvania Perelman School of Medicine, 3400 Spruce St, Philadelphia, PA 19104.
Shampa ChatterjeeFrom the Laboratory for Structural, Physiologic and Functional Imaging, Department of Radiology (A.C., M.C.L., A.J., F.W.W.), Department of Biostatistics and Epidemiology (W.G.), and Institute for Environmental Medicine and Department of Physiology (S.C.), University of Pennsylvania Perelman School of Medicine, 3400 Spruce St, Philadelphia, PA 19104.
Felix W WehrliFrom the Laboratory for Structural, Physiologic and Functional Imaging, Department of Radiology (A.C., M.C.L., A.J., F.W.W.), Department of Biostatistics and Epidemiology (W.G.), and Institute for Environmental Medicine and Department of Physiology (S.C.), University of Pennsylvania Perelman School of Medicine, 3400 Spruce St, Philadelphia, PA 19104.ORCID 0000-0003-3430-1840
University of Pennsylvania · US

Funding

MRI Assessment of Vascular ReactivityR01HL109545 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WEHRLI, FELIX W · 2011 to 2014
$2.1M
MRI and Serum Markers of Endothelial Stress Resulting from E-Cigarette Aerosol InhalationR01HL139358 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WEHRLI, FELIX W · 2017 to 2020
$1.9M
NHLBI NIH HHS R01 HL109545NHLBI NIH HHS R01 HL139358
6 · The paper itself

Abstract

Background Previous studies showed that nicotinized electronic cigarettes (hereafter, e-cigarettes) elicit systemic oxidative stress and inflammation. However, the effect of the aerosol alone on endothelial function is not fully understood. Purpose To quantify surrogate markers of endothelial function in nonsmokers after inhalation of aerosol from nicotine-free e-cigarettes. Materials and Methods In this prospective study (from May to September 2018), nonsmokers underwent 3.0-T MRI before and after inhaling nicotine-free e-cigarette aerosol. Peripheral vascular reactivity to cuff-induced ischemia was quantified by temporally resolving blood flow velocity and oxygenation (SvO

Indexed as

Electronic Nicotine Delivery SystemsAdultBlood Flow VelocityEndothelium, VascularEvaluation Studies as TopicFemaleFemoral ArteryFemoral VeinHumansMagnetic Resonance ImagingMaleProspective StudiesPulse Wave AnalysisVapingYoung Adult

Identifiers

PMID31429679
PMCPMC6776371
OpenAlexW2969791325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.