ArticleJournal of veterinary internal medicine2019
Development of a comprehensive protein microarray for immunoglobulin E profiling in horses with severe asthma.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Genomic Epidemiology of Fungi Identified in Bronchoalveolar Lavage Fluid from Asthmatic Horses in the US.Animals : an open access journal from MDPI · 2026Article
- Article
- Association between equine asthma and fungal elements in the tracheal wash: An environment-matched case-control study.PloS one · 2024Article
- Protein microarray allergen profiling in bronchoalveolar lavage fluid and serum of horses with asthma.Journal of veterinary internal medicine · 2023Article
- Immunoproteomics reveal increased serum IgG3/5 binding toFrontiers in immunology · 2023Article
- Characterization of fungal exposure and dectin-1 expression in healthy horses and horses with severe asthma.American journal of veterinary research · 2022Article
- First clinical expression of equine insect bite hypersensitivity is associated with co-sensitization to multiple Culicoides allergens.PloS one · 2021Article
- Antigen array for serological diagnosis and novel allergen identification in severe equine asthma.Scientific reports · 2019Article
- Development of a comprehensive protein microarray for immunoglobulin E profiling in horses with severe asthma.Journal of veterinary internal medicine · 2019Article
- Microarray molecular mapping of horses with severe asthma.Journal of veterinary internal medicineArticle
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundSevere asthma in horses, known as severe equine asthma (SEA), is a prevalent, performance-limiting disease associated with increased allergen-specific immunoglobulin E (IgE) against a range of environmental aeroallergens.
objectiveTo develop a protein microarray platform to profile IgE against a range of proven and novel environmental proteins in SEA-affected horses. ANIMALS: Six SEA-affected and 6 clinically healthy Warmblood performance horses.
methodsDeveloped a protein microarray (n = 384) using protein extracts and purified proteins from a large number of families including pollen, bacteria, fungi, and arthropods associated with the horses, environment. Conditions were optimized and assessed for printing, incubation, immunolabeling, biological fluid source, concentration techniques, reproducibility, and specificity.
resultsThis method identified a number of novel allergens, while also identifying an association between SEA and pollen sensitization. Immunolabeling methods confirmed the accuracy of a commercially available mouse anti-horse IgE 3H10 source (R CONCLUSIONS AND CLINICAL IMPORTANCE: We have established that protein microarrays can be used for large-scale IgE mapping of allergens associated with the environment of horses. This technology provides a sound platform for specific diagnosis, management, and treatment of SEA.
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