Evidence map›Paper›PMID 31429450›Full record

ArticleChemical communications (Cambridge, England)2019

Expanding the biological utility of bis-NHC gold(i) complexes through post synthetic carbamate conjugation.

Sajal Sen, Yue Li, Vincent Lynch, Kuppuswamy Arumugam, Jonathan L Sessler, Jonathan F Arambula

Open access · greenAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 28 citations in OpenAlex.

  1. Three Is Better than One: A Multimetal Complex that Triggers Immunogenic Cell Death.Angewandte Chemie (International ed. in English) · 2025
    Article
  2. Article
  3. Reaction Behavior of [1,3-Diethyl-4,5-diphenyl-1Journal of medicinal chemistry · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sajal SenDepartment of Chemistry, University of Texas at Austin, Austin, TX 78712-1224, USA. sessler@cm.utexas.edu jfarambula@cm.utexas.edu.
Yue Li
Vincent Lynch
Kuppuswamy Arumugam
Jonathan L Sessler
Jonathan F Arambula
The University of Texas at Austin · USWright State University · US

Funding

Biomedical Applications of Expanded Porphyrins: Development of Gold-Texaphyrin ConjugatesR01CA068682 · NCI · UNIVERSITY OF TEXAS AUSTIN · PI Esther Y. Maier, Emily L Que · 1995 to 2026
$7.4M
Dual Targeting Redox‐active Gold(I) TherapeuticsR15CA232765 · NCI · WRIGHT STATE UNIVERSITY · PI ARUMUGAM, KUPPUSWAMY · 2018 to 2018
$462k
NCI NIH HHS R01 CA068682NCI NIH HHS R15 CA232765
6 · The paper itself

Abstract

We report the synthesis of a novel hydroxyl-functionalised heteroleptic bis-NHC gold(i) complex that permits conjugation to various amines via carbamate bond formation. The resulting derivatives were studied in vitro using cell proliferation assays and fluorescent microscopic imaging of human cancer cell lines.

Indexed as

A549 CellsAminesAntineoplastic AgentsCarbamatesCell ProliferationCell SurvivalCoordination ComplexesDoxorubicinFluorescent DyesGoldHumansOptical ImagingThioredoxin-Disulfide ReductaseTriazolesAminesAntineoplastic AgentsCarbamatesCoordination ComplexesDoxorubicinFluorescent DyesGoldThioredoxin-Disulfide ReductaseTriazoles

Identifiers

PMID31429450
PMCPMC7039396
OpenAlexW2967176225

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.