ReviewJournal of the International Association of Providers of AIDS Care
HIV-Related Cerebral Toxoplasmosis Revisited: Current Concepts and Controversies of an Old Disease.
Review in Journal of the International Association of Providers of AIDS Care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 171 citations in OpenAlex.
- Partial pupil-sparing third nerve palsy as a manifestation of cerebral toxoplasmosis in an HIV-positive patient: A case report.American journal of ophthalmology case reports · 2026Article
- Clofazimine against cerebral toxoplasmosis in diabetic and dexamethasone-immunosuppressed mice: ultrastructural and semiquantitative transmission electron microscopic study.BMC neuroscience · 2026Article
- Next-Generation Vaccines Against Neglected Diseases: New Promises from Genetically Modified Live-Attenuated Parasites and RNA Vaccines.Microorganisms · 2026Review
- One Health, many voices: advances and challenges in toxoplasmosis discussed at the VII Brazilian symposium and IV international symposium on toxoplasmosis.One health outlook · 2026Article
- Spinal Cord Toxoplasmosis: Mapping the Journey of a Rare Entity Through a Case Report and Review of the Literature.Microorganisms · 2026Article
- Cerebral toxoplasmosis in the twenty-first century.AIDS (London, England) · 2026Observational
- Cerebral toxoplasmosis: Parasitology, diagnosis, treatment, and prevention - a narrative review.Current research in parasitology & vector-borne diseases · 2026Review
- Central Nervous System Toxoplasmosis is an Under-Recognized Opportunistic infection in Uganda.Journal of tropical medicine · 2026Article
- Toxoplasma gondii seropositivity among patients with sickle cell disease: Prevalence and association with blood transfusion history.PloS one · 2026Article
- Clinical utility of plasma microbial cell-free DNA sequencing for early diagnosis of toxoplasmosis in high-risk patients: a five-patient case series.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Case Report: Immune reconstitution-related neurological deterioration in advanced HIV infection with multiple opportunistic infections: a diagnostic challenge.Frontiers in medicine · 2026Article
- Neurological Infections in HIV: A Case-Based Review for Clinicians.Le infezioni in medicina · 2026Review
- Knowledge, Attitudes, and Practices Toward Toxoplasmosis Among Veterinary and Human Health Professionals in Central Ethiopia.Veterinary medicine international · 2026Article
- Toxoplasmic encephalitis unmasked during treatment for miliary tuberculosis in a patient with human immunodeficiency virus infection: a case report and literature review.Tropical medicine and health · 2025Article
- Toxoplasma gondii infection diagnosed by tNGS in a patient with acute lymphoblastic leukemia: a case report.BMC infectious diseases · 2025Article
- Mapping amBio · 2025Article
- Tartrolon E rapidly blocks Toxoplasma gondii capacity to invade host cells.International journal for parasitology. Drugs and drug resistance · 2025Article
- Clinical and imaging characteristics of toxoplasmic encephalitis in patients with HIV/AIDS with different immune statuses.Quantitative imaging in medicine and surgery · 2025Article
- Clinical courses and outcomes of cerebral toxoplasmosis in HIV-positive patients in Shiraz, Southern Iran: a retrospective study.BMC infectious diseases · 2025Article
- Detection of toxoplasma tachyzoites in the cerebrospinal fluid of a COVID-19 positive SLE patient: a case study.BMC infectious diseases · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral toxoplasmosis is the most common cause of expansive brain lesions in people living with HIV/AIDS (PLWHA) and continues to cause high morbidity and mortality. The most frequent characteristics are focal subacute neurological deficits and ring-enhancing brain lesions in the basal ganglia, but the spectrum of clinical and neuroradiological manifestations is broad. Early initiation of antitoxoplasma therapy is an important feature of the diagnostic approach of expansive brain lesions in PLWHA. Pyrimethamine-based regimens and trimethoprim-sulfamethoxazole (TMP-SMX) seem to present similar efficacy, but TMP-SMX shows potential practical advantages. The immune reconstitution inflammatory syndrome is uncommon in cerebral toxoplasmosis, and we now have more effective, safe, and friendly combined antiretroviral therapy (cART) options. As a consequence of these 2 variables, the initiation of cART can be performed within 2 weeks after initiation of antitoxoplasma therapy. Herein, we will review historical and current concepts of epidemiology, diagnosis, and treatment of HIV-related cerebral toxoplasmosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.