Evidence map›Paper›PMID 31429211›Full record

ReviewWiley interdisciplinary reviews. RNA2020

Approaches for measuring the dynamics of RNA-protein interactions.

Donny D Licatalosi, Xuan Ye, Eckhard Jankowsky

Open access · greenAbstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. RNA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Dynamics and Regulation of mRNA Cap Recognition by Human eIF4F.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Computational tools to study RNA-protein complexes.Frontiers in molecular biosciences · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Donny D LicatalosiCenter for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, Ohio.ORCID 0000-0002-2047-6298
Xuan YeCenter for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Eckhard JankowskyCenter for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, Ohio.ORCID 0000-0001-7677-7412
Case Western Reserve University · US

Funding

Enzymes and enzyme complexes in RNA metabolismR35GM118088 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI JANKOWSKY, ECKHARD · 2016 to 2022
$4.3M
Ptbp2 function and global mRNA regulation during mammalian cell developmentR01GM107331 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI LICATALOSI, DONNY D · 2013 to 2022
$2.8M
NIGMS NIH HHS R01 GM107331NIGMS NIH HHS R35 GM118088
6 · The paper itself

Abstract

RNA-protein interactions are pivotal for the regulation of gene expression from bacteria to human. RNA-protein interactions are dynamic; they change over biologically relevant timescales. Understanding the regulation of gene expression at the RNA level therefore requires knowledge of the dynamics of RNA-protein interactions. Here, we discuss the main experimental approaches to measure dynamic aspects of RNA-protein interactions. We cover techniques that assess dynamics of cellular RNA-protein interactions that accompany biological processes over timescales of hours or longer and techniques measuring the kinetic dynamics of RNA-protein interactions in vitro. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications RNA Interactions with Proteins and Other Molecules > Protein-RNA Recognition RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes RNA Evolution and Genomics > Ribonomics.

Indexed as

AnimalsHumansKineticsRNARNA-Binding ProteinsRNARNA-Binding ProteinsCLIPenzymeFRETkineticsRNA binding protein

Identifiers

PMID31429211
PMCPMC7006490
OpenAlexW2969765780

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.