ArticlePest management science2020
Multiple channels of DEET repellency in Drosophila.
Article in Pest management science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Multimodal targets of (-)-α-thujone mediating avoidance behavior of a stored-products pest, Tribolium castaneum, in response to irritant stimuli.Pest management science · 2026Article
- Transcriptional responses of Aedes aegypti chemosensory tissues in response to volatile DEET and citronella oil.Insect molecular biology · 2026Article
- Reducing Close Encounters with Insect Pests and Vectors: The Past, Present and Future of Insect Repellents.Insects · 2026Review
- HL-IR mediates cinnamaldehyde repellency behavior in parthenogenetic Haemaphysalis longicornis.PLoS neglected tropical diseases · 2025Article
- Harnessing Insect Chemosensory and Mechanosensory Receptors Involved in Feeding for Precision Pest Management.Life (Basel, Switzerland) · 2025Review
- Binary mixtures of Vanderbilt University allosteric agonist thermolysis components act as volatile spatial repellents for malaria vector mosquitoes.Pest management science · 2025Article
- Recent advances in degradation of N,N-diethyl-3-toluamide (DEET)-an emerging environmental contaminant: a review.Environmental monitoring and assessment · 2024Review
- Arthropod repellent interactions with olfactory receptors and ionotropic receptors analyzed by molecular modeling.Current research in insect science · 2024Article
- Identification of 2,4-Di-International journal of molecular sciences · 2023Article
- Diverse mechanisms of taste coding inScience advances · 2023Article
- Review
- Review
- Cellular and molecular mechanisms of DEET toxicity and disease-carrying insect vectors: a review.Genes & genomics · 2020Review
- Exposure to N,N-Diethyl-Meta-Toluamide Insect Repellent and Human Health Markers: Population Based Estimates from the National Health and Nutrition Examination Survey.The American journal of tropical medicine and hygiene · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundN,N-Diethyl-meta-toluamide (DEET) is the prophylactic insect repellent used most widely to inhibit insect bites. Despite its use since 1944, the mechanism of DEET repellency remains controversial. Here, we revisited the role of smell and taste in DEET repellence using Drosophila as a model.
resultsAnalysis of the responses of individual olfactory receptor neuron (ORN) classes to DEET reveals that 11 ORNs are activated and two are inhibited by this compound. Blocking individual ORN classes in the antenna does not block DEET repellence. This argues against the existence of a single ORN mediating DEET repellence in Drosophila. Activation of all ORCO-expressing neurons using channelrhodopsin favors attraction, not repellence, in behavioral valence. We also demonstrate that gustatory neurons are highly sensitive to DEET. We used RNA interference to screen candidate receptors encoded by gene families involved in the detection of bitter compounds, including 34 gustatory receptors (Grs), 14 ionotropic receptors (Irs), five pick-pocket subunits (PPKs), three transient receptor potential ion channels (TrpA, TrpL, Painless) and one metabotropic glutamate receptors gene (DmXR). We saw striking defects in DEET-mediated oviposition behavior when expression of either Gr32a or Gr33a was inhibited.
conclusionOur findings support a multimodal mechanism for DEET detection in fruit flies and indicate a prominent role for taste detection mediating DEET repellence. © 2019 Society of Chemical Industry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.