SynthesisWorld journal of surgery2019
A Systematic Review of Opt-out Versus Opt-in Consent on Deceased Organ Donation and Transplantation (2006-2016).
Synthesis in World journal of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Education and Ethical Guidance for Organ Donation at the End-of-Life: An Ethical Guidance Statement from the Neurocritical Care Society.Neurocritical care · 2026Review
- Skin cancer detection and organ donation.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Article
- Does opt-out legislation crowd out living organ donations? A cross-country study.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Article
- Assessment of the relationship between organ donation attitudes and religious beliefs among postgraduate students.Frontiers in public health · 2025Article
- Protocol and Statistical Analysis Plan for a Comparative Interrupted Time Series Evaluation of the Impact of Deemed Consent for Organ Donation Legislative Reform in Nova Scotia, Canada.Transplantation direct · 2024Article
- Awareness and Willingness towards Organ Donation among Riyadh Residents: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2024Article
- Evaluation of liver transplantation services in Kazakhstan from 2012 to 2023.Scientific reports · 2024Article
- The role of healthcare professionals to improve organ donation and transplantation outcome: a national study.Cell and tissue banking · 2024Article
- Early experiences of deemed consent legislation for organ donation in Nova Scotia: a qualitative study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024Article
- Heart transplantation: advances in expanding the donor pool and xenotransplantation.Nature reviews. Cardiology · 2024Review
- Article
- Post-COVID-19 pandemic organ donation activities in Germany: a multicenter retrospective analysis.Frontiers in public health · 2024Article
- Trends in organ donation in England, Scotland and Wales in the context of the COVID-19 pandemic and 'opt-out' legislation.PloS one · 2024Article
- A novel risk score for predicting prolonged length of stay following pediatric kidney transplant.Pediatric nephrology (Berlin, Germany) · 2023Article
- Organ Donation Awareness among Family Members of ICU Patients.Medicina (Kaunas, Lithuania) · 2023Article
- Global liver transplantation: emerging trends and ethical challenges.Langenbeck's archives of surgery · 2023Review
- NHS staff awareness, attitudes and actions towards the change in organ donation law in England-results of the #options survey 2020.Archives of public health = Archives belges de sante publique · 2023Article
- Organ and Tissue Donation Consent Model and Intent to Donate Registries: Recommendations From an International Consensus Forum.Transplantation direct · 2023Article
- Baseline Ethical Principles and a Framework for Evaluation of Policies: Recommendations From an International Consensus Forum.Transplantation direct · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundSignificant numbers of patients in the USA and UK die while waiting for solid organ transplant. Only 1-2% of deaths are eligible as donors with a fraction of the deceased donating organs. The form of consent to donation may affect the organs available. Forms of consent include: opt-in, mandated choice, opt-out, and organ conscription. Opt-in and opt-out are commonly practiced. A systematic review was conducted to determine the effect of opt-in versus opt-out consent on the deceased donation rate (DDR) and deceased transplantation rate (DTR).
methodsLiterature searches of PubMed and EMBASE between 2006 and 2016 were performed. Research studies were selected based on certain inclusion criteria which include USA, UK, and Spain; compare opt-in versus opt-out; primary data analysis; and reported DDR or DTR. Modeled effect on US transplant activity was conducted using public data from Organ Procurement and Transplantation Network and Centers for Disease Control WONDER from 2006 to 2015.
resultsA total of 2400 studies were screened and six studies were included. Four studies reported opt-out consent increases DDR by 21-76% over 5-14 years. These studies compared 13-25 opt-out countries versus 9-23 opt-in countries. Three studies reported opt-out consent increases DTR by 38-83% over 11-13 years. These studies compared 22-25 opt-out versus 22-28 opt-in countries. Modeled opt-out activity on the USA resulted in 4753-17,201 additional transplants annually.
conclusionOpt-out consent increases DDR and DTR and may be useful in decreasing deaths on the waiting list in the USA and other countries. REGISTRATION NUMBER: PROSPERO CRD42019098759.
Indexed as
Identifiers
31428836What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.