Evidence map›Paper›PMID 31428775›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020

The Longevity-Associated SH2B3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects.

Chia-Ling Kuo, Micaella Joaquim, George A Kuchel, Luigi Ferrucci, Lorna W Harries, Luke C Pilling, David Melzer

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
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  11. Genes and Longevity of Lifespan.International journal of molecular sciences · 2022
    Review
  12. Germline risk of clonal haematopoiesis.Nature reviews. Genetics · 2021
    Review
  13. The genetics of human ageing.Nature reviews. Genetics · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Chia-Ling KuoConnecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington.
Micaella JoaquimCollege of Medicine and Health, University of Exeter, UK.
George A KuchelCenter on Aging, University of Connecticut Health School of Medicine, Farmington.
Luigi FerrucciNational Institute on Aging, Baltimore, Maryland.
Lorna W HarriesCollege of Medicine and Health, University of Exeter, UK.
Luke C PillingCollege of Medicine and Health, University of Exeter, UK.
David MelzerCollege of Medicine and Health, University of Exeter, UK.
University of Exeter · GBUConn Health · USNational Institute on Aging · US

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/M023095/1
6 · The paper itself

Abstract

Human SH2B3 is involved in growth factor and inflammation signaling. A SH2B3 missense variant (rs3184504) is associated with cardiovascular diseases plus breast, colorectal, and lung cancers, with highly correlated variants across the ATXN2/SH2B3/BRAP locus linked to parental age at death, suggesting a geroscience common mechanism of aging and disease. To better understand the SH2B3-related aging pathway and its potential as an intervention target, we undertook a phenotype-wide association study (PheWAS) of 52 aging traits. Data were obtained from 379,758 European-descent UK Biobank participants, aged 40-70 at baseline: 27% of participants were CC homozygotes and 23% TT at rs3184504. Parental extreme longevity (mothers aged ≥98 years, fathers aged ≥96 years) was more common in CC versus TT (odds ratio [OR] = 1.18, 95% confidence interval [CI]: 1.07 to 1.29) with an additive per allele effect. The C allele associated with better cognitive function and white blood cell counts were more likely to be normal. The C allele reduced risks of coronary heart disease (OR = 0.95, 95% CI: 0.93 to 0.96) but was also associated with a modestly higher cancer rate (OR = 1.03, 95% CI: 1.02 to 1.04), suggesting a trade-off across aging outcomes and limiting its potential as an anti-aging target.

Indexed as

Adaptor Proteins, Signal TransducingAdultAgedAged, 80 and overAllelesBiomarkersDatabases as TopicFemaleGenetic Association StudiesGenetic VariationHumansLongevityMaleMiddle AgedParentsPolymorphism, Single NucleotideAdaptor Proteins, Signal TransducingBiomarkersSH2B3 protein, humanAnti-agingCancerCentenarianIGF-1UK Biobank

Identifiers

PMID31428775
PMCPMC7749196
OpenAlexW2969663657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.