ArticleBioactive materials2019
In vitro and in vivo biocompatibility of Mg-Zn-Ca alloy operative clip.
Article in Bioactive materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 56 citations in OpenAlex.
- Surface Coatings on Biomedical Magnesium Alloys.Materials (Basel, Switzerland) · 2025Review
- Mg-Zn-Ca Alloy with Ultra-High Ductility and Strength Processed by Screw Rolling.Materials (Basel, Switzerland) · 2025Article
- The Recent Developments of Thermomechanical Processing for Biomedical Mg Alloys and Their Clinical Applications.Materials (Basel, Switzerland) · 2025Review
- In Vitro and In Vivo Analysis of the Mg-Ca-Zn Biodegradable Alloys.Journal of functional biomaterials · 2024Article
- In vivo performance of a rare earth free Mg-Zn-Ca alloy manufactured using twin roll casting for potential applications in the cranial and maxillofacial fixation devices.Bioactive materials · 2022Article
- Osteogenesis, angiogenesis and immune response of Mg-Al layered double hydroxide coating on pure Mg.Bioactive materials · 2021Article
- Article
- Corrosion Resistance and Biocompatibility Assessment of a Biodegradable Hydrothermal-Coated Mg-Zn-Ca Alloy: An in Vitro and in Vivo Study.ACS omega · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At present, titanium (Ti) and its alloys are most commonly use in hemostasis clip clinical applications. However, the Ti Clip cannot be absorbed in human body and produce artifacts on computed tomography (CT), and induce clinically relevant hypersensitivity in patients. In order to overcome the drawbacks of the non-degradable Ti clips, an Mg-Zn-Ca alloy operative clip was fabricated by combining hot extrusion and blanking processing. In vitro and in vivo biocompatibility of Mg-Zn-Ca alloy operative clip were evaluated by L-929 Cells and SD rat model respectively. It was found that Mg-Zn-Ca alloy exhibited non-cytotoxic to L929 cells. In vivo implantation showed that the newly designed Mg-Zn-Ca clip can successfully ligated carotid artery and no blood leakage occurred post-surgery. During the period of the clip degradation, a small amount of H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.