Evidence map›Paper›PMID 31428693›Full record

ArticleCommunications biology2019

Extracellular vesicles secreted by

Kening Zhao, Mark Bleackley, David Chisanga, Lahiru Gangoda, Pamali Fonseka, Michael Liem, Hina Kalra, Haidar Al Saffar, Shivakumar Keerthikumar, Ching-Seng Ang and 8 more

Abstract read
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Multifunctional Bioactivity ofMolecules (Basel, Switzerland) · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Growth conditions shape the proteome and diversity ofCell surface (Amsterdam, Netherlands) · 2025
    Article
  12. Article
  13. Fungal Chitin Synthases: Structure, Function, and Regulation.Journal of fungi (Basel, Switzerland) · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Functional properties ofMicrobiology (Reading, England) · 2025
    Article
  18. Article
  19. Article
  20. Review

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kening Zhao *1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia.
Mark Bleackley *1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia.ORCID 0000-0002-9717-7560
David Chisanga2Department of Computer Science and Information Technology, La Trobe University, Melbourne, VIC 3086 Australia.ORCID 0000-0002-0421-3957
Lahiru Gangoda1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia.
Pamali Fonseka1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia.
Michael Liem1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia.
Hina Kalra1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia.
Haidar Al Saffar1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia.
Shivakumar Keerthikumar1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia.
Ching-Seng Ang5Bio21 Institute, University of Melbourne, Melbourne, VIC 3010 Australia.
Christopher G Adda1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia.
Lanzhou Jiang1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia.
Kuok Yap6ARC Centre of Excellence in Plant Cell Walls and Adelaide Glycomics, The University of Adelaide, Waite Campus, Urrbrae, SA 5064 Australia.
Ivan K Poon1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia.ORCID 0000-0002-9119-7173
Peter Lock1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia.ORCID 0000-0003-4421-3609
Vincent Bulone6ARC Centre of Excellence in Plant Cell Walls and Adelaide Glycomics, The University of Adelaide, Waite Campus, Urrbrae, SA 5064 Australia.
Marilyn Anderson1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia.ORCID 0000-0002-8257-5128
Suresh Mathivanan1Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086 Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are membranous vesicles that are released by cells. In this study, the role of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery in the biogenesis of yeast EVs was examined. Knockout of components of the ESCRT machinery altered the morphology and size of EVs as well as decreased the abundance of EVs. In contrast, strains with deletions in cell wall biosynthesis genes, produced more EVs than wildtype. Proteomic analysis highlighted the depletion of ESCRT components and enrichment of cell wall remodelling enzymes, glucan synthase subunit Fks1 and chitin synthase Chs3, in yeast EVs. Interestingly, EVs containing Fks1 and Chs3 rescued the yeast cells from antifungal molecules. However, EVs from

Indexed as

Antifungal AgentsCaspofunginCell SurvivalCell WallEndosomal Sorting Complexes Required for TransportExtracellular VesiclesMutationProteomicsSaccharomyces cerevisiaeStress, PhysiologicalAntifungal AgentsCaspofunginEndosomal Sorting Complexes Required for TransportBiotechnologyESCRTFungal biologyProteomics

Identifiers

PMID31428693
PMCPMC6688994

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.