ArticleJournal of immunology research2019
Similar Transition Processes in Synovial Fibroblasts from Rheumatoid Arthritis and Osteoarthritis: A Single-Cell Study.
Article in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Revealing the Diagnostic Potential of Three RHO GTPase-Related Genes in Osteoarthritis Based on Single-Cell RNA Sequencing and GEO Dataset Analysis.International journal of genomics · 2026Article
- Identification of Antibodies to Chondrocyte and Synoviocyte Antigens in Equine Osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- ER O-glycosylation in synovial fibroblasts drives cartilage degradation.Nature communications · 2025Article
- Exploring The Role of TOP2A in the Intersection of Pathogenic Mechanisms Between Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis Based on Bioinformatics.Journal of inflammation research · 2025Article
- Advancing skeletal health and disease research with single-cell RNA sequencing.Military Medical Research · 2024Review
- Single-cell RNA sequencing in osteoarthritis.Cell proliferation · 2023Review
- Identification of the candidate genes of diagnosing rheumatoid arthritis using the single-cell sequencing technology and T cell subclusters analysis of patients with rheumatoid arthritis.Archives of rheumatology · 2023Article
- Single-cell RNA sequencing in orthopedic research.Bone research · 2023Review
- Single-Cell Sequencing in Rheumatic Diseases: New Insights from the Perspective of the Cell Type.Aging and disease · 2022Article
- Back to basics: Transcriptomics studies for deep phenotyping of osteoarthritis.Osteoarthritis and cartilage open · 2021Article
- An up to date on clinical prospects and management of osteoarthritis.Annals of medicine and surgery (2012) · 2021Review
- The FcεRI signaling pathway is involved in the pathogenesis of lacrimal gland benign lymphoepithelial lesions as shown by transcriptomic analysis.Scientific reports · 2021Article
- Beneficial Effect of Tempol, a Membrane-Permeable Radical Scavenger, on Inflammation and Osteoarthritis in In Vitro Models.Biomolecules · 2021Article
- The Application of Single-Cell RNA Sequencing in Studies of Autoimmune Diseases: a Comprehensive Review.Clinical reviews in allergy & immunology · 2021Review
- BMSC-derived exosomes from congenital polydactyly tissue alleviate osteoarthritis by promoting chondrocyte proliferation.Cell death discovery · 2020Article
- CXCL1 contributes to IL-6 expression in osteoarthritis and rheumatoid arthritis synovial fibroblasts by CXCR2, c-Raf, MAPK, and AP-1 pathway.Arthritis research & therapy · 2020Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) and osteoarthritis (OA) are common rheumatic disorders that primarily involve joints. The inflammation of the synovium can be observed in both of the two diseases. Synovial fibroblasts (SFs) play an important role in the inflammatory process of the synovium. The functional states of synovial fibroblasts are heterogeneous, and the detailed transition process of their functional states is still unclear. By using transcriptomic data of SFs at a single-cell level, we found a similar transition process for SFs in RA and OA. We also identified the potential regulatory effects of the WNT signaling pathway, the TGF-
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