Evidence map›Paper›PMID 31428634›Full record

Trial reportBioMed research international2019

Technical Verification and Assessment of Independent Validation of Biomarker Models for Endometriosis.

Dorien F O, Amelie Fassbender, Rita Van Bree, Annouschka Laenen, Daniëlle P Peterse, Arne Vanhie, Etienne Waelkens, Thomas M D'Hooghe

Open access · hybridAbstract readClinical TrialValidation Study
In one paragraph

Trial report in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Challenges in uncovering non-invasive biomarkers of endometriosis.Experimental biology and medicine (Maywood, N.J.) · 2020
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Dorien F OKU Leuven Department of Development and Regeneration, Woman and Child, 3000 Leuven, Belgium.ORCID https://orcid.org/0000-0003-0426-9325
Amelie FassbenderKU Leuven Department of Development and Regeneration, Woman and Child, 3000 Leuven, Belgium.
Rita Van BreeKU Leuven Department of Development and Regeneration, Woman and Child, 3000 Leuven, Belgium.
Annouschka LaenenKU Leuven Department of Public Health and Primary Care, Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), 3000 Leuven, Belgium.
Daniëlle P PeterseKU Leuven Department of Development and Regeneration, Woman and Child, 3000 Leuven, Belgium.
Arne VanhieKU Leuven Department of Development and Regeneration, Woman and Child, 3000 Leuven, Belgium.
Etienne WaelkensSYBIOMA, Facility for Systems Biology Based Mass Spectrometry, 3000 Leuven, Belgium.
Thomas M D'HoogheKU Leuven Department of Development and Regeneration, Woman and Child, 3000 Leuven, Belgium.ORCID https://orcid.org/0000-0002-2373-8257
KU Leuven · BELeuven Institute for Fertility and Embryology · BECenter for Systems Biology · USStatistics Belgium · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a great need for a noninvasive diagnosis for endometriosis. Several biomarkers and biomarker panels have been proposed. Biomarker models consisting of CA-125, VEGF, Annexin V, and glycodelin/sICAM-1 were previously developed by our group. The objective of our current study was to assess the impact of technical and biological variability on the performance of those previously developed prediction models in a technical verification and a validation setting. The technical verification cohort consisted of peripheral blood plasma samples from a subset of the patients included in the original study of Vodolazkaia

Indexed as

Models, BiologicalAdultAnnexin A5BiomarkersCA-125 AntigenEndometriosisFemaleHumansIntercellular Adhesion Molecule-1Annexin A5BiomarkersCA-125 AntigenICAM1 protein, humanIntercellular Adhesion Molecule-1

Identifiers

PMID31428634
PMCPMC6683797
OpenAlexW2962821252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.