Evidence map›Paper›PMID 31428630›Full record

SynthesisBioMed research international2019

The Additional Effect of Autologous Platelet Concentrates to Coronally Advanced Flap in the Treatment of Gingival Recessions: A Systematic Review and Meta-Analysis.

Rong Li, Yanqing Liu, Tong Xu, Haijiao Zhao, Jingya Hou, Yun Wu, Dongmei Zhang

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04248049 (Clinical Evaluation of Coronal Advanced Flap and Platelet Rich Fibrin on Root Coverage of Gingival Recessions Over a Period of 24 Month.), which is not on this map. Cited by 23 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04248049 nacompletednot on this map

Clinical Evaluation of Coronal Advanced Flap and Platelet Rich Fibrin on Root Coverage of Gingival Recessions Over a Period of 24 Month.

TypeinterventionalSponsorUniversidad Antonio NariñoRan2018 to 2019Enrolled15ConditionsGingival RecessionArmsPlatelet rich fibrin
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  12. A New Matrix for Soft Tissue Management.Journal of clinical medicine · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rong LiDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.ORCID https://orcid.org/0000-0001-6232-2337
Yanqing LiuDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.
Tong XuDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.
Haijiao ZhaoDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.
Jingya HouDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.
Yun WuDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.
Dongmei ZhangDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.ORCID https://orcid.org/0000-0001-6180-0253

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo improve the efficacy of regenerative treatment for gingival recessions, the autologous platelet concentrates (APCs) combined with coronally advanced flap (CAF) have been investigated. However, few studies systematically assess the complementary effect of APCs in periodontal regeneration. The present study aims to evaluate the additional effect of different types of APCs to CAF in the treatment of gingival recessions.

methodsElectronic databases (EMBASE, MEDLINE, and Cochrane Central Register of Controlled Trails) and relevant journals were searched until May 15, 2019. Only randomized controlled trials (RCTs) in English were included. Outcome variables include root coverage (RC), recession depth (RD), clinical attachment level (CAL), keratinized tissue width (KTW), and gingival thickness (GT). Data were analyzed with Revman5.3. The estimate of effect sizes was expressed as the mean differences and the 95% confidence interval.

results8 RCTs involving 170 patients (328 sites) were included. Our meta-analysis indicated RC, RD, CAL, KTW, and GT were better improved in the CAF plus APCs groups than the CAF alone. The subgroup analyses revealed that platelet-rich fibrin (PRF) brought significant improvement in RC, RD, CAL, and GT. Concentrated growth factors (CGF) lead clinic beneficial in CAL, KTW, and GT. No significant effect of platelet-rich plasma (PRP) could be found in any clinical parameters when combined with CAF.

conclusionsPRF could exert additional effect to CAF; the preferred treatment for gingival recessions was considered. Based on the limited studies, it seemed that PRP failed to show any additional effect and it was not suggested for gingival recessions. Given the limited research and high risk of bias, it is still needed to confirm the additional effect of CGF by more high-quality studies.

Indexed as

Blood PlateletsGingival RecessionPlatelet-Rich FibrinSurgical FlapsWound HealingHumansSurgical Wound

Identifiers

PMID31428630
PMCPMC6683801

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.