ArticleImmunometabolism2019
Netrin-1 Alters Adipose Tissue Macrophage Fate and Function in Obesity.
Article in Immunometabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 51 citations in OpenAlex.
- The Serpin Superfamily in Adipose Tissue Remodeling: Molecular Drivers of Immune-Metabolic Crosstalk and Insulin Sensitivity.Biology · 2026Review
- Netrin-1 disrupt high-fat-diet-induced adipogenesis via the PPARγ and Wnt/β-catenin signaling pathways.Communications biology · 2026Article
- Unveiling the significance of Netrin-1 and Netrin-4 in metabolic syndrome.Scientific reports · 2026Article
- Rna analysis of the regulation of expression and alternative splicing in polycystic ovarian syndrome.RNA biology · 2025Article
- Neural function of Netrin-1 in precancerous lesions of the pancreas.Nature communications · 2025Article
- Netrin-1 and RGMa: Novel Regulators of Atherosclerosis-Related Diseases.Cardiovascular drugs and therapy · 2025Review
- Opposing profiles of Netrin-1 and adiponectin in metabolic inflammation and insulin resistance.Frontiers in pharmacology · 2025Article
- Targeting Unc5b in macrophages drives atherosclerosis regression and pro-resolving immune cell function.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Unraveling the complex roles of macrophages in obese adipose tissue: an overview.Frontiers of medicine · 2024Review
- Activation of vascular endothelial cells by synovial fibrosis promotes Netrin-1-induced sensory nerve sprouting and exacerbates pain sensitivity.Journal of cellular and molecular medicine · 2023Article
- Role of Inflammatory Processes in the Brain-Body Relationship Underlying Hypertension.Current hypertension reports · 2023Review
- Impact of intestinal microenvironments in obesity and bariatric surgery on shaping macrophages.Immunometabolism (Cobham, Surrey) · 2023Review
- Adipose tissue at single-cell resolution.Cell metabolism · 2023Review
- Increased Expression Levels of Netrin-1 in Visceral Adipose Tissue during Obesity Favour Colon Cancer Cell Migration.Cancers · 2023Article
- Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance.Nutrients · 2022Article
- Macrophages, Low-Grade Inflammation, Insulin Resistance and Hyperinsulinemia: A Mutual Ambiguous Relationship in the Development of Metabolic Diseases.Journal of clinical medicine · 2022Review
- Identification of candidate biomarkers and pathways associated with type 1 diabetes mellitus using bioinformatics analysis.Scientific reports · 2022Article
- CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Review
- The Role of LTB4 in Obesity-Induced Insulin Resistance Development: An Overview.Frontiers in endocrinology · 2022Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
Macrophages accumulate prominently in the visceral adipose tissue (VAT) of obese humans and high fat diet (HFD) fed mice, and this is linked to insulin resistance and type II diabetes. While the mechanisms regulating macrophage recruitment in obesity have been delineated, the signals directing macrophage persistence in VAT are poorly understood. We previously showed that the neuroimmune guidance cue netrin-1 is expressed in the VAT of obese mice and humans, where it promotes macrophage accumulation. To better understand the source of netrin-1 and its effects on adipose tissue macrophage (ATM) fate and function in obesity, we generated mice with myeloid-specific deletion of netrin-1 (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.