ArticleClinical hypertension2019
Familial aggregation and heritability of hypertension in Han population in Shanghai China: a case-control study.
Article in Clinical hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 17 citations in OpenAlex.
- Multidimensional Mechanisms of Hypertension and Advances in Diagnosis and Integrated TCM-Based Treatment: A Review.International journal of general medicine · 2026Review
- Household Aggregation of Hypertension in India: A Cross-Sectional Study of Nationally Representative Data From 450 000 Households.Journal of the American Heart Association · 2025Article
- Hypertension Prevalence Among People Lifted Out of Poverty in China in 2018-2023: Retrospective Spatiotemporal Analysis.JMIR public health and surveillance · 2025Article
- Biobank-scale methods and projections for sparse polygenic prediction from machine learning.Scientific reports · 2023Article
- Association of blood pressure and hypertension between parents and offspring: The Korea National Health and Nutrition Examination Survey.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Family History of Hypertension and Cobalt Exposure Synergistically Promote the Prevalence of Hypertension.Biological trace element research · 2022Article
- Association Between ABCA1 Gene Polymorphisms and the Risk of Hypertension in the Chinese Han Population.Frontiers in public health · 2022Article
- The interaction on hypertension between family history and diabetes and other risk factors.Scientific reports · 2021Article
- High Blood Pressure-A High Risk Problem for Public Healthcare.Current health sciences journalArticle
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5 authors.
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Abstract
backgroundTo explore the familial aggregation and heritability of hypertension in Han in Shanghai China.
methodsAccording to l:l matched pairs design, 342 patients of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The method of genetic epidemiology research was used to explore the familial aggregation and heritability of hypertension.
resultsThe prevalence rate of hypertension of first-degree relatives was significantly higher (34.44%) than that of second- degree relatives (17.60%) and third-degree relatives (13.51%) in Han Population in Shanghai China. Separation ratio p was 0.217, and prevalence rate of case group relatives was higher than that of control group relatives. The results showed a phenomenon of familial aggregation in the distribution of hypertension. The heritability of first- degree relatives was 49.51%; that of second-degree relatives and third-degree relatives were respectively 23.42 and 21.41%.
conclusionThe distribution of essential hypertension has phenomenon of familial aggregation in Han Population in Shanghai China. The separation ratio of essential hypertension in this study shows that essential hypertension conform to the characteristics of multigene genetic disease. The heritability of first-degree relatives is bigger than that of second-degree relatives and third-degree relatives.
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