Evidence map›Paper›PMID 31428447›Full record

ArticleFuture science OA2019

Predictive value and clinical significance of increased SSAT-1 activity in healthy adults.

Paramjit S Tappia, Andrew W Maksymiuk, Daniel S Sitar, Parveen S Akhtar, Nazrina Khatun, Rahnuma Parveen, Rashiduzzaman Ahmed, Rashid B Ahmed, Brian Cheng, Gina Huang and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04530006 (Acetyl-Amantadine as a Biomarker in Patients With Glioblastoma), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04530006 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Acetyl-Amantadine as a Biomarker in Patients With Glioblastoma

TypeinterventionalSponsorCancerCare ManitobaRan2020 to 2025Enrolled20ConditionsGlioblastoma MultiformeArmsAmantadine Hydrochloride
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. The Association between Spermidine/Spermine NInternational journal of molecular sciences · 2022
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Paramjit S TappiaAsper Clinical Research Institute & Office of Clinical Research, St Boniface Hospital, Winnipeg, MB, R2H 2A6, Canada.
Andrew W MaksymiukCancer Care Manitoba, Winnipeg, MB, R3E 0V9, Canada.
Daniel S SitarDepartment of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, R3A 1R9, Canada.
Parveen S AkhtarDepartment of Medical Oncology, National Institute of Cancer Research & Hospital, Mohakhali, Dhaka, Bangladesh.
Nazrina KhatunDepartment of Medical Oncology, National Institute of Cancer Research & Hospital, Mohakhali, Dhaka, Bangladesh.
Rahnuma ParveenDepartment of Medical Oncology, National Institute of Cancer Research & Hospital, Mohakhali, Dhaka, Bangladesh.
Rashiduzzaman AhmedFastBios, Dhaka, Bangladesh.
Rashid B AhmedBioMark Diagnostics Inc., Richmond, BC, V6X 2W8, Canada.
Brian ChengBioMark Diagnostics Inc., Richmond, BC, V6X 2W8, Canada.
Gina HuangBioMark Diagnostics Inc., Richmond, BC, V6X 2W8, Canada.
Horacio BachDivision of Infectious Diseases, Faculty of Medicine, University of British Columbia, Vancouver, BC, V5Z 3J5, Canada.
Brett HiebertCardiac Sciences Program, Asper Clinical Research Institute, Winnipeg, MB, R2H 2A6, Canada.
Bram RamjiawanAsper Clinical Research Institute & Office of Clinical Research, St Boniface Hospital, Winnipeg, MB, R2H 2A6, Canada.
National Institute of Cancer Research and Hospital · BDSt. Boniface Hospital · CACancerCare Manitoba · CAUniversity of British Columbia · CAUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimSpermidine/spermine N MATERIALS &

methodsA follow up of urine analysis for AA by liquid chromatography-tandem mass spectrometry as well as clinical assessments and additional blood analyses were conducted.

resultsIn some of the outlier controls, higher than expected AA concentration was linked to increased serum carcinoembryonic antigen. Clinical and radiographic assessments revealed underlying abnormalities in other cases that could represent premalignant conditions. Hematology tests revealed elevations in white blood cells and platelets, which are markers of inflammation.

conclusionHigh urine concentration of AA could be used as a simple and useful test for screening of cancer in high-risk populations.

Indexed as

amantadinebiomarkerscancer screening and diagnosticsearly detectionSSAT-1

Identifiers

PMID31428447
PMCPMC6695528
OpenAlexW2955622181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.