Evidence map›Paper›PMID 31428227›Full record

ReviewOxidative medicine and cellular longevity2019

Alpha-2-Macroglobulin, a Hypochlorite-Regulated Chaperone and Immune System Modulator.

Jordan H Cater, Mark R Wilson, Amy R Wyatt

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
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  4. Trial
  5. Human α2-Macroglobulin: Architecture, Mechanisms, and Functional Implications.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
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  7. Intracellular Signaling Regulated by Activated αInternational journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jordan H CaterIllawarra Health and Medical Research Institute and School of Chemistry and Molecular Bioscience, University of Wollongong, New South Wales 2522, Australia.
Mark R WilsonIllawarra Health and Medical Research Institute and School of Chemistry and Molecular Bioscience, University of Wollongong, New South Wales 2522, Australia.
Amy R WyattIllawarra Health and Medical Research Institute and School of Chemistry and Molecular Bioscience, University of Wollongong, New South Wales 2522, Australia.ORCID https://orcid.org/0000-0002-3650-2438
University of Wollongong · AUFlinders University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alpha-macroglobulins are ancient proteins that include monomeric, dimeric, and tetrameric family members. In humans, and many other mammals, the predominant alpha-macroglobulin is alpha-2-macroglobulin (

Indexed as

Amyloid beta-PeptidesAnimalsHumansHypochlorous AcidImmune SystemNeurodegenerative DiseasesPeptide HydrolasesPregnancy-Associated alpha 2-MacroglobulinsProtein BindingSignal TransductionAmyloid beta-PeptidesHypochlorous AcidPeptide HydrolasesPregnancy-Associated alpha 2-Macroglobulins

Identifiers

PMID31428227
PMCPMC6679887
OpenAlexW2964143009

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.