Evidence map›Paper›PMID 31428223›Full record

ArticleOxidative medicine and cellular longevity2019

Antidepressant and Antiaging Effects of Açaí (

José Rogério Souza-Monteiro, Gabriela P F Arrifano, Ana Isabelle D G Queiroz, Bruna S F Mello, Charllyany S Custódio, Danielle S Macêdo, Moisés Hamoy, Ricardo S O Paraense, Leonardo O Bittencourt, Rafael R Lima and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 47 citations in OpenAlex.

  1. Clarified açaí (Euterpe oleracea Martius) exerts protective effects against methylmercury toxicity in salivary glands and total saliva.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  2. Article
  3. Article
  4. Açai (Heliyon · 2024
    Article
  5. Review
  6. Review
  7. What We Know aboutNutrients · 2023
    Article
  8. Açaí (Nutrients · 2023
    Review
  9. Neuroprotective effects of açaí (Frontiers in pharmacology · 2023
    Article
  10. Article
  11. Extract ofFrontiers in cellular neuroscience · 2022
    Article
  12. Açaí (Food & nutrition research · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. The Use ofBiomolecules · 2020
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

José Rogério Souza-MonteiroLaboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Gabriela P F ArrifanoLaboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Ana Isabelle D G QueirozLaboratory of Neuropharmacology, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.ORCID https://orcid.org/0000-0002-1289-0675
Bruna S F MelloLaboratory of Neuropharmacology, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.
Charllyany S CustódioLaboratory of Neuropharmacology, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.
Danielle S MacêdoLaboratory of Neuropharmacology, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.
Moisés HamoyLaboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Ricardo S O ParaenseLaboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Leonardo O BittencourtLaboratory of Structural and Functional Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.ORCID https://orcid.org/0000-0002-9525-2723
Rafael R LimaLaboratory of Structural and Functional Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.ORCID https://orcid.org/0000-0003-1486-4013
Rommel R BurbanoLaboratory of Molecular Biology, Ophir Loyola Hospital, Belém, Pará, Brazil.
Hervé RogezCentre for Valorisation of Amazonian Bioactive Compounds (CVACBA) and Federal University of Pará, Belém, Brazil.
Cristiane F MaiaLaboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Federal University of Pará, Belém, PA, Brazil.ORCID https://orcid.org/0000-0003-4493-7375
Barbarella M MacchiLaboratory of Molecular and Cellular Neurochemistry, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
José Luiz M do NascimentoLaboratory of Molecular and Cellular Neurochemistry, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.ORCID https://orcid.org/0000-0003-3475-4778
Maria Elena Crespo-LópezLaboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.ORCID https://orcid.org/0000-0002-1335-6853
Universidade Federal do Pará · BRUniversidade Federal do Ceará · BRUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression is a mental disorder that affects 300 million people of all ages worldwide, but fewer than half of those with the condition receive adequate treatment. In addition, the high pharmacological refractoriness (affecting 30%-50% of patients) and toxicity of some classical antidepressants support the pursuit of new therapies. People with this condition show depressed mood, loss of pleasure, high levels of oxidative stress, and accelerated biological aging (decreased telomere length and expression of the telomerase reverse transcriptase (TERT), the enzyme responsible for telomere maintenance). Because of the close relationship between depression and oxidative stress, nutraceuticals with antioxidant properties are excellent candidates for therapy. This study represents the first investigation of the possible antidepressant and antiaging effects of commercial samples of clarified açaí (

Indexed as

AnimalsAntidepressive AgentsAntioxidantsBehavior, AnimalBrainDepressive DisorderEuterpeFruitHippocampusLipid PeroxidationLipopolysaccharidesLocomotionMaleMicePlant ExtractsTelomeraseAntidepressive AgentsAntioxidantsLipopolysaccharidesPlant ExtractsTelomeraseTert protein, mouse

Identifiers

PMID31428223
PMCPMC6681600
OpenAlexW2963833028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.