ReviewFrontiers in plant science2019
The Origin and Evolution of Plant Flavonoid Metabolism.
Review in Frontiers in plant science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers.
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Who cites it
193 citing papers in PubMed, 465 citations in OpenAlex.
- Cytochrome P450 enzymes in the phenylpropanoid pathway: CYP73 and CYP98 candidate genes in Chara braunii, Anthoceros agrestis, Marchantia polymorpha and Physcomitrium patens.The Plant journal : for cell and molecular biology · 2026Article
- OsEPSPS Balances Disease Resistance and Plant Growth.Plant, cell & environment · 2026Article
- Variety-Specific Metabolomic Configurations Underlie Differences in Seed Color, Nutritional Quality, and Antioxidant Activity of Faba Bean (Plants (Basel, Switzerland) · 2026Article
- The Biosynthesis of a Fungal Flavonoid, Chlorflavonin, Precisely Controlled by Two Types of Equilibrium States.Journal of the American Chemical Society · 2026Article
- Unveiling Dynamic Defense Pathways: Transcriptome Analysis of Phenylpropanoids and (Iso)flavonoids in Cowpea Leaves Post-CABMV Inoculation.Biochemical genetics · 2026Article
- Plant Flavonoids: Biosynthesis, Regulation, and Roles in Biotic and Abiotic Stresses.Plant, cell & environment · 2026Review
- Article
- The Metabolome of theJournal of natural products · 2026Review
- Untargeted metabolomics suggests a trade-off between phenolamides and flavonoids in the pollen of Petunia hybrida with contrasting flower colours.BMC plant biology · 2026Article
- DupyliCate: mining, classifying, and characterizing gene duplications.Scientific reports · 2026Article
- Integrative transcriptomic and metabolomic profiling elucidates the metabolic network underlying development in Salsola collina.BMC plant biology · 2026Article
- Loss of flavonol 3-O-glucosyltransferase activity confers soybean resistance to leaf-chewing insects.The Plant journal : for cell and molecular biology · 2026Article
- Article
- Impact of sulfamethoxazole, trimethoprim, diclofenac, carbamazepine, and their mixture on the metabolism of Lemna minor: a targeted metabonomic study.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Open data phylometabolomics reveals turnover-dominated chemical divergence and clade-specific physicochemical regimes across angiosperms.The Plant journal : for cell and molecular biology · 2026Article
- Molecular insights into the regulation of flavonoid biosynthesis in fruits.Horticulture research · 2026Article
- Transcriptomic and metabolomic analyses reveal the role of flavonoids in ectomycorrhizal symbiosis.Mycorrhiza · 2026Article
- Nanotechnology-Enhanced Delivery and Bioactivity of Dietary Flavonoids: Overcoming Bioavailability Barriers for Targeted Antimicrobial and Antiviral Therapies-A Comprehensive Review.International journal of nanomedicine · 2026Review
- Traditional and Innovative Processing of Georgian Myrobalan Plum (Food science & nutrition · 2026Article
- Integrative metabolomic and transcriptomic analyses reveal the regulatory mechanisms underlying the biosynthesis of flavonoid and terpenoid metabolites in different tissues ofFrontiers in plant science · 2026Article
133 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During their evolution, plants have acquired the ability to produce a huge variety of compounds. Unlike the specialized metabolites that accumulate in limited numbers of species, flavonoids are widely distributed in the plant kingdom. Therefore, a detailed analysis of flavonoid metabolism in genomics and metabolomics is an ideal way to investigate how plants have developed their unique metabolic pathways during the process of evolution. More comprehensive and precise metabolite profiling integrated with genomic information are helpful to emerge unexpected gene functions and/or pathways. The distribution of flavonoids and their biosynthetic genes in the plant kingdom suggests that flavonoid biosynthetic pathways evolved through a series of steps. The enzymes that form the flavonoid scaffold structures probably first appeared by recruitment of enzymes from primary metabolic pathways, and later, enzymes that belong to superfamilies such as 2-oxoglutarate-dependent dioxygenase, cytochrome P450, and short-chain dehydrogenase/reductase modified and varied the structures. It is widely accepted that the first two enzymes in flavonoid biosynthesis, chalcone synthase, and chalcone isomerase, were derived from common ancestors with enzymes in lipid metabolism. Later enzymes acquired their function by gene duplication and the subsequent acquisition of new functions. In this review, we describe the recent progress in metabolomics technologies for flavonoids and the evolution of flavonoid skeleton biosynthetic enzymes to understand the complicate evolutionary traits of flavonoid metabolism in plant kingdom.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.