Evidence map›Paper›PMID 31428081›Full record

ArticleFrontiers in immunology2019

Mass Cytometry Discovers Two Discrete Subsets of CD39

Felix Marsh-Wakefield, Annabel Kruzins, Helen M McGuire, Shihong Yang, Christian Bryant, Barbara Fazekas de St Groth, Najah Nassif, Scott N Byrne, John Gibson, Christina Brown and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

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  10. Mechanisms of Allergen Immunotherapy in Allergic Rhinitis.Current allergy and asthma reports · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Felix Marsh-WakefieldDiscipline of Infectious Diseases and Immunology, Faculty of Medicine and Health, Central Clinical School, The University of Sydney, Sydney, NSW, Australia.
Annabel KruzinsSchool of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.
Helen M McGuireRamaciotti Facility for Human Systems Biology, The University of Sydney, Sydney, NSW, Australia.
Shihong YangRoyal Prince Alfred Hospital, Institute of Haematology, Sydney, NSW, Australia.
Christian BryantRoyal Prince Alfred Hospital, Institute of Haematology, Sydney, NSW, Australia.
Barbara Fazekas de St GrothRamaciotti Facility for Human Systems Biology, The University of Sydney, Sydney, NSW, Australia.
Najah NassifSchool of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.
Scott N ByrneDiscipline of Infectious Diseases and Immunology, Faculty of Medicine and Health, Central Clinical School, The University of Sydney, Sydney, NSW, Australia.
John GibsonRoyal Prince Alfred Hospital, Institute of Haematology, Sydney, NSW, Australia.
Christina BrownRoyal Prince Alfred Hospital, Institute of Haematology, Sydney, NSW, Australia.
Stephen LarsenRoyal Prince Alfred Hospital, Institute of Haematology, Sydney, NSW, Australia.
Derek McCullochRoyal Prince Alfred Hospital, Institute of Haematology, Sydney, NSW, Australia.
Richard BoyleOrthopaedics Department, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Georgina ClarkConcord Repatriation General Hospital, ANZAC Research Institute, Concord, NSW, Australia.
Douglas JoshuaRoyal Prince Alfred Hospital, Institute of Haematology, Sydney, NSW, Australia.
Phoebe Joy HoRoyal Prince Alfred Hospital, Institute of Haematology, Sydney, NSW, Australia.
Slavica VuckovicRoyal Prince Alfred Hospital, Institute of Haematology, Sydney, NSW, Australia.
Royal Prince Alfred Hospital · AUUniversity of Sydney · AUUniversity of Technology Sydney · AUConcord Repatriation General Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple Myeloma (MM) is preceded by the clinically stable condition monoclonal gammopathy of undetermined significance (MGUS). Critical immune events that discriminate MGUS from newly diagnosed MM (ND)MM patients remain unknown, but may involve changes in the regulatory T cell (Treg) compartment that favor myeloma growth. To address this possibility, we used mass cytometry and the unsupervised clustering algorithm Flow self-organizing map (FlowSOM) to interrogate the distribution of multiple subsets within CD25

Indexed as

AdultAgedAged, 80 and overApyraseBone MarrowFemaleFlow CytometryHumansImmunophenotypingLeukocyte Common AntigensMaleMiddle AgedMonoclonal Gammopathy of Undetermined SignificanceMultiple MyelomaProgrammed Cell Death 1 ReceptorReceptors, ImmunologicApyraseENTPD1 protein, humanLeukocyte Common AntigensProgrammed Cell Death 1 ReceptorReceptors, ImmunologicFlowSommass cytometryMGUSmultiple myelomaTreg

Identifiers

PMID31428081
PMCPMC6688400
OpenAlexW2964931238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.