ArticleFrontiers in systems neuroscience2019
Neuroradiological Changes Following Single or Repetitive Mild TBI.
Article in Frontiers in systems neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Characteristic patterns of white matter tract injury in sport-related concussion: An image based meta-analysis.NeuroImage. Clinical · 2020Pooled it
- Longitudinal MAP-MRI-based Assessment of Tissue Microstructural Alterations in Acute mTBI.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Sex differences in plasma endocannabinoids and related lipids before and after single and repeated mTBI: an exploratory study of endolipid plasma biomarkers.Frontiers in molecular neuroscience · 2026Article
- MRI investigation of orientation-dependent changes in microstructure and function in a mouse model of mild traumatic brain injury.Acta neuropathologica communications · 2025Article
- The normative modelling framework for traumatic brain injury.Brain : a journal of neurology · 2025Review
- Sex Differences in Plasma Levels of Endocannabinoids and Related Lipids Before and After acute and repeated mTBI: an exploratory study for plasma biomarkers for mTBI.bioRxiv : the preprint server for biology · 2025Article
- Multimodal Magnetic Resonance Imaging with Mild Repetitive Head Injury in Awake Rats: Modeling the Human Experience and Clinical Condition.Neuroscience bulletin · 2025Article
- Mapping global brain reconfigurations following local targeted manipulations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- History of Traumatic Brain Injury Does Not Influence Rate of Progression of Clinical or Pathological Outcomes in Two Early Parkinson's Disease Cohorts.European journal of neurology · 2025Observational
- Individualized mouse brain network models produce asymmetric patterns of functional connectivity after simulated traumatic injury.Network neuroscience (Cambridge, Mass.) · 2025Article
- Functional Connectivity, Tissue Microstructure, and T2 at 11.1 Tesla Distinguishes Neuroadaptive Differences in Two Traumatic Brain Injury Models in Rats: A Translational Outcomes Project in NeuroTrauma (TOP-NT) UG3 Phase Study.Neurotrauma reports · 2025Article
- Following changes in brain structure and function with multimodal MRI in a year-long prospective study on the development of Type 2 diabetes.Frontiers in radiology · 2025Article
- Changes in cerebral vascular reactivity following mild repetitive head injury in awake rats: modeling the human experience.Experimental brain research · 2024Article
- Mild repetitive TBI reduces brain-derived neurotrophic factor (BDNF) in the substantia nigra and hippocampus: A preclinical model for testing BDNF-targeted therapeutics.Experimental neurology · 2024Article
- The imprint of dissociative seizures on the brain.NeuroImage. Clinical · 2024Article
- Multi-Mechanistic Approaches to the Treatment of Traumatic Brain Injury: A Review.Journal of clinical medicine · 2023Review
- Volumetric MRI Findings in Mild Traumatic Brain Injury (mTBI) and Neuropsychological Outcome.Neuropsychology review · 2023Review
- Regional associations of white matter integrity and neurological, post-traumatic stress disorder and autonomic symptoms in Veterans with and without history of loss of consciousness in mild TBI.Frontiers in neuroimaging · 2023Article
- Blink-related EEG oscillations are neurophysiological indicators of subconcussive head impacts in female soccer players: a preliminary study.Frontiers in human neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo test the hypothesis that there are differences in neuroradiological measures between single and repeated mild traumatic brain injury using multimodal MRI.
methodsA closed-head momentum exchange model was used to produce one or three mild head injuries in young adult male rats compared to non-injured, age and weight-matched controls. Six-seven weeks post-injury, rats were studied for deficits in cognitive and motor function. Seven-eight weeks post-injury changes in brain anatomy and function were evaluated through analysis of high resolution T2 weighted images, resting-state BOLD functional connectivity, and diffusion weighted imaging with quantitative anisotropy.
resultsHead injuries occurred without skull fracture or signs of intracranial bleeding or contusion. There were no significant differences in cognitive or motors behaviors between experimental groups. With a single mild hit, the affected areas were limited to the caudate/putamen and central amygdala. Rats hit three times showed altered diffusivity in white matter tracts, basal ganglia, central amygdala, brainstem, and cerebellum. Comparing three hits to one hit showed a similar pattern of change underscoring a dose effect of repeated head injury on the brainstem and cerebellum. Disruption of functional connectivity was pronounced with three mild hits. The midbrain dopamine system, hippocampus, and brainstem/cerebellum showed hypoconnectivity. Interestingly, rats exposed to one hit showed
interpretationNeuroradiological evidence of altered brain structure and function, particularly in striatal and midbrain dopaminergic areas, persists long after mild repetitive head injury. These changes may serve as biomarkers of neurodegeneration and risk for dementia later in life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.