ArticleMediators of inflammation2019
Interleukin-18 Expression Increases in the Aorta and Plasma of Patients with Acute Aortic Dissection.
Article in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Vasculoprotective Potential of Baicalein in Angiotensin II-Infused Abdominal Aortic Aneurysms through Inhibiting Inflammation and Oxidative Stress.International journal of molecular sciences · 2023Article
- Single-Cell RNA-Seq Analysis Reveals Macrophages Are Involved in the Pathogenesis of Human Sporadic Acute Type A Aortic Dissection.Biomolecules · 2023Article
- Risk Factors for Aortic Dissection.US cardiology · 2023Review
- The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections.European journal of clinical investigation · 2022Review
- Dysregulation of interaction between LOXTheranostics · 2022Article
- Review
- Association ofFrontiers in cardiovascular medicine · 2021Article
- The Role of Macrophages in Aortic Dissection.Frontiers in physiology · 2020Review
- Increased Epicardial Adipose Tissue is Associated with the Extent of Aortic Dissection.Journal of the Saudi Heart Association · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInterleukin- (IL-) 18 is a proinflammatory cytokine related to cardiovascular diseases, including hypertension and atherosclerosis. This study is aimed at determining whether IL-18 is related to aortic dissection (AD) and identifying the underlying mechanisms.
methodsIL-18 expression in human aorta samples from AD (
resultsIL-18 expression was significantly increased in the aorta samples from the AD patients compared with those from the NAD patients, especially in the torn section. Aortic IL-18 was mainly derived from macrophages and also partly derived from CD4+ T lymphocytes and vascular SMCs. Plasma IL-18, IFN-
conclusionIL-18 may participate in AD by regulating macrophage differentiation and macrophage-induced SMC apoptosis.
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Registered trials
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