ArticleNature biomedical engineering2020
Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve.
Article in Nature biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 76 citations in OpenAlex.
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- The optimization of neuroprosthetic interfaces relying on biophysical and surrogate digital twins.npj biomedical innovations · 2026Review
- Brain-Computer Interfaces for Vision Recovery in Precortical Vision Loss.Eye and brain · 2026Review
- Advances in artificial vision systems: a comprehensive review of technologies, applications, and future directions.Biomedical engineering letters · 2025Review
- Machine Learning Techniques for Simulating Human Psychophysical Testing of Low-Resolution Phosphene Face Images in Artificial Vision.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Flexible graphene-based neurotechnology for high-precision deep brain mapping and neuromodulation in Parkinsonian rats.Nature communications · 2025Article
- Transcorneal Electrical Stimulation Modulates Visual Pathway Function in Mice.Journal of neuroscience research · 2025Article
- Article
- Aligning Visual Prosthetic Development With Implantee Needs.Translational vision science & technology · 2024Article
- Aligning visual prosthetic development with implantee needs.medRxiv : the preprint server for health sciences · 2024Article
- Decoding electroencephalographic responses to visual stimuli compatible with electrical stimulation.APL bioengineering · 2024Article
- An Ultrasensitive Biomimetic Optic Afferent Nervous System with Circadian Learnability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Noninvasive imaging-guided ultrasonic neurostimulation with arbitrary 2D patterns and its application for high-quality vision restoration.Nature communications · 2024Article
- Article
- An actor-model framework for visual sensory encoding.Nature communications · 2024Article
- Cortico-muscular connectivity is modulated by passive and active Lokomat-assisted Gait.Scientific reports · 2023Article
- Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?Antioxidants (Basel, Switzerland) · 2023Review
- Bioresorbable thin-film silicon diodes for the optoelectronic excitation and inhibition of neural activities.Nature biomedical engineering · 2023Article
- Ultrasound Retinal Stimulation: A Mini-Review of Recent Developments.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Review
- Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022Article
Corrections and comments
- Commented on by
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal prostheses can restore a functional form of vision in patients affected by dystrophies of the outer retinal layer. Beyond clinical utility, prostheses for the stimulation of the optic nerve, the visual thalamus or the visual cortex could also serve as tools for studying the visual system. Optic-nerve stimulation is particularly promising because it directly activates nerve fibres, takes advantage of the high-level information processing occurring downstream in the visual pathway, does not require optical transparency and could be effective in cases of eye trauma. Here we show, in anaesthetized rabbits and with support from numerical modelling, that an intraneural electrode array with high mechanical stability placed in the intracranial segment of the optic nerve induces, on electrical stimulation, selective activation patterns in the visual cortex. These patterns are measured as electrically evoked cortical potentials via an ECoG array placed in the contralateral cortex. The intraneural electrode array should enable further investigations of the effects of electrical stimulation in the visual system and could be further developed as a visual prosthesis for blind patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.