ArticleNature neuroscience2019
Reward revaluation biases hippocampal replay content away from the preferred outcome.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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Who cites it
46 citing papers in PubMed.
- Goal-directed hippocampal theta sweeps during memory-guided navigation.Nature neuroscience · 2026Article
- Article
- Prefrontal-thalamic goal states organize spatially aligned hippocampal maps.Nature communications · 2026Article
- Planning in the Brain: It's Not What You Think It Is.Annual review of neuroscience · 2026Review
- Distinct goal location beta frequency dynamics in hippocampus and prefrontal cortex across learning.bioRxiv : the preprint server for biology · 2026Article
- Article
- Between planning and map building: Prioritizing replay when future goals are uncertain.Neuron · 2025Review
- Replay without sharp wave ripples in a spatial memory task.Nature communications · 2025Article
- Prioritizing replay when future goals are unknown.bioRxiv : the preprint server for biology · 2025Article
- Goal-specific hippocampal inhibition gates learning.Nature · 2025Article
- Hippocampal output suppresses orbitofrontal cortex schema cell formation.Nature neuroscience · 2025Article
- Article
- The recursive grammar of mental time travel.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Selective reactivation of value- and place-dependent information during sharp-wave ripples in the intermediate and dorsal hippocampus.Science advances · 2024Article
- Article
- A recurrent network model of planning explains hippocampal replay and human behavior.Nature neuroscience · 2024Article
- Paradoxical replay can protect contextual task representations from destructive interference when experience is unbalanced.bioRxiv : the preprint server for biology · 2024Article
- Article
- Internal-state-dependent control of feeding behavior via hippocampal ghrelin signaling.Neuron · 2024Article
- The role of experience in prioritizing hippocampal replay.Nature communications · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rodent hippocampus spontaneously generates bursts of neural activity (replay) that can depict spatial trajectories to reward locations, suggesting a role in model-based behavioral control. A largely separate literature emphasizes reward revaluation as the litmus test for such control, yet the content of hippocampal replay under revaluation conditions is unknown. We examined the content of awake replay events following motivational shifts between hunger and thirst. On a T-maze offering free choice between food and water outcomes, rats shifted their behavior toward the restricted outcome, but replay content was shifted away from the restricted outcome. This effect preceded experience on the task each day and did not reverse with experience. These results demonstrate that replay content is not limited to reflecting recent experience or trajectories toward the preferred goal and suggest a role for motivational states in determining replay content.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.