ArticleMolecular psychiatry2020
Association between major depressive disorder and multiple disease outcomes: a phenome-wide Mendelian randomisation study in the UK Biobank.
Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Dissecting the shared genetic landscape of anxiety, depression, and schizophrenia.Journal of translational medicine · 2024Pooled it
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Prevalence and clinical features of depressed adolescents co-occurring insomnia and excessive daytime sleepiness symptoms.European archives of psychiatry and clinical neuroscience · 2026Article
- Proactive consultation-liaison-services (CL): comparing PHQ-4 screening with traditional referral pathways in medical inpatients - a prospective comparative pilot study.BMC psychiatry · 2026Article
- Testing bidirectional associations of major depressive disorder with medical conditions: two-sample Mendelian randomization study.Npj mental health research · 2026Article
- Frailty, depressive symptoms, and incident respiratory disease: a CHARLS cohort study.BMC pulmonary medicine · 2026Article
- Genetic susceptibility to depression and risk of cardiometabolic diseases: a systematic review and meta-analysis of 21 Mendelian randomisation studies.EClinicalMedicine · 2025Article
- Depression and incidence of inflammation-related physical health conditions: a cohort study in UK Biobank.BMC psychiatry · 2025Article
- Association between depression and asthma: insight from observational and genetic evidence.BMC psychiatry · 2025Observational
- Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology.Psychological medicine · 2025Article
- Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research.Molecular psychiatry · 2025Review
- An encompassing Mendelian randomization study of the causes and consequences of major depressive disorder.Nature. Mental health · 2025Article
- Investigating the Causal Relationship and Shared Genetic Basis Between Major Depression Disorder and Eight Types of Gastrointestinal Diseases.Genetics research · 2025Article
- Disruption of Lipid Profile, Glucose Metabolism, and Leptin Levels following Citalopram Administration and High-Carbohydrate and High-Cholesterol Diet in Mice.Pharmacology · 2025Article
- Association of clinical phenotypes of depression with comorbid conditions, treatment patterns and outcomes: a 10-year region-based cohort study.Translational psychiatry · 2024Observational
- Mood instability and risk of gastrointestinal diseases - a univariable and multivariable mendelian randomization study.Annals of general psychiatry · 2024Article
- Application of polygenic scores to a deeply phenotyped sample enriched for substance use disorders reveals extensive pleiotropy with psychiatric and somatic traits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Bridging Three Years of Insights: Examining the Association Between Depression and Gallstone Disease.Journal of clinical medicine research · 2024Article
- Causal influence of gut microbiota on small cell lung cancer: a Mendelian randomization study.The clinical respiratory journal · 2024Article
- Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants.BMC medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 3 countries.
Funding
Abstract
Depression affects all aspects of an individual's life but evidence relating to the causal effects on health is limited. We used information from 337,536 UK Biobank participants and performed hypothesis-free phenome-wide association analyses between major depressive disorder (MDD) genetic risk score (GRS) and 925 disease outcomes. GRS-disease outcome associations passing the multiple-testing corrected significance threshold (P < 1.9 × 10
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.