Evidence map›Paper›PMID 31427746›Full record

ArticleNature nanotechnology2019

Remotely controlled chemomagnetic modulation of targeted neural circuits.

Siyuan Rao, Ritchie Chen, Ava A LaRocca, Michael G Christiansen, Alexander W Senko, Cindy H Shi, Po-Han Chiang, Georgios Varnavides, Jian Xue, Yang Zhou and 5 more

Abstract read
In one paragraph

Article in Nature nanotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 114 citations in OpenAlex.

  1. Article
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  5. Article
  6. Genetics-Based Targeting Strategies for Precise Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
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  15. Article
  16. Article
  17. Article
  18. The New Era of Neural Modulation Led by Smart Nanomaterials.International journal of nanomedicine · 2024
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Siyuan RaoResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ritchie ChenSimons Center for Social Brain, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ava A LaRoccaDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Michael G ChristiansenResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Alexander W SenkoResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Cindy H ShiDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Po-Han ChiangResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Georgios VarnavidesResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8338-3323
Jian XueMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Yang ZhouMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Seongjun ParkResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1981-9628
Ruihua DingJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Junsang MoonResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8683-5540
Guoping FengMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8021-277X
Polina AnikeevaResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA. anikeeva@mit.edu.ORCID http://orcid.org/0000-0001-6495-5197
Massachusetts Institute of Technology · USMcGovern Institute for Brain Research · USHarvard University · USSimons Foundation · USETH Zurich · CH

Funding

Multi-Site Non-Invasive Magnetothermal Excitation and Inhibition of Deep Brain StructuresR01MH111872 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANIKEEVA, POLINA O, PRALLE, ARND · 2016 to 2019
$3.6M
NIMH NIH HHS R01 MH111872
6 · The paper itself

Abstract

Connecting neural circuit output to behaviour can be facilitated by the precise chemical manipulation of specific cell populations

Indexed as

Drug Delivery SystemsAnimalsBehavior, AnimalCells, CulturedDelayed-Action PreparationsLiposomesMagnetic FieldsMagnetite NanoparticlesMaleMiceMice, Inbred C57BLNerve NetNeurotransmitter AgentsRatsTemperatureVentral Tegmental AreaDelayed-Action PreparationsLiposomesMagnetite NanoparticlesNeurotransmitter Agents

Identifiers

PMID31427746
PMCPMC6778020
OpenAlexW2969362372

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.