Evidence map›Paper›PMID 31427736›Full record

ArticleOncogene2019

Induction of NKG2D ligand expression on tumor cells by CD8

Jiemiao Hu, Xueqing Xia, Richard Gorlick, Shulin Li

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jiemiao HuDivision of Pediatrics, Department of Pediatrics Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xueqing XiaDivision of Pediatrics, Department of Pediatrics Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Richard GorlickDivision of Pediatrics, Department of Pediatrics Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Shulin LiDivision of Pediatrics, Department of Pediatrics Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Sli4@mdanderson.org.
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Gene-Product Auto-Targeting to Tumor VesselsR01CA120895 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LI, SHULIN · 2007 to 2025
$4.8M
Tumor-Targeted Chemo-Immunotherapy for Osteosarcoma MetastasisR01CA200574 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LI, SHULIN, ZHANG, LIANGFANG · 2016 to 2020
$1.8M
NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA120895NCI NIH HHS R01 CA200574
6 · The paper itself

Abstract

The ligands for the natural killer group 2 (NKG2D) protein render tumor cells susceptible to NKG2D-dependent immune cell attack. However, cancer cells escape from immune surveillance by downregulating NKG2D ligands. We previously discovered that engagement of activated CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCytokinesHumansKiller Cells, NaturalMiceMice, Inbred BALB CMice, Inbred C57BLNeoplasmsNF-kappa BNK Cell Lectin-Like Receptor Subfamily KNuclear Matrix-Associated ProteinsNucleocytoplasmic Transport Proteinsp300-CBP-Associated Factorp300-CBP Transcription FactorsReceptors, Tumor Necrosis FactorCytokinesKLRK1 protein, humanKlrk1 protein, mouseNF-kappa BNK Cell Lectin-Like Receptor Subfamily KNuclear Matrix-Associated ProteinsNucleocytoplasmic Transport Proteinsp300-CBP-Associated Factorp300-CBP Transcription FactorsRAE1 protein, humanRae1 protein, mouseReceptors, Tumor Necrosis Factor

Identifiers

PMID31427736
PMCPMC6895417
OpenAlexW2967072015

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.