ArticleScientific reports2019
An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Adipocytes as core drivers of skin aging and novel targets for regeneration.Biogerontology · 2026Review
- 4-week aerobic exercise training regulates systemic macrophage polarization in obese mice.PeerJ · 2026Article
- Sex-specific body fat distribution predicts cardiovascular ageing.European heart journal · 2025Article
- Poor clinical outcomes among hospitalized obese patients with COVID-19 are related to inflammation and not respiratory mechanics.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Article
- Enhancing adipose tissue functionality in obesity: senotherapeutics, autophagy and cellular senescence as a target.Biological research · 2024Review
- Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases.Signal transduction and targeted therapy · 2024Review
- Resistance and Aerobic Training Were Effective in Activating Different Markers of the Browning Process in Obesity.International journal of molecular sciences · 2023Article
- Differential remodeling of subcutaneous white and interscapular brown adipose tissue by long-term exercise training in aged obese female mice.Journal of physiology and biochemistry · 2023Article
- The impact of metabolic endotoxaemia on the browning process in human adipocytes.BMC medicine · 2023Article
- Hematopoietic Stem Cells and the Immune System in Development and Aging.International journal of molecular sciences · 2023Review
- Increased Secreted Frizzled-Related Protein 5 mRNA Expression in the Adipose Tissue of Women with Nonalcoholic Fatty Liver Disease Associated with Obesity.International journal of molecular sciences · 2022Article
- Review
- The shades of grey in adipose tissue reprogramming.Bioscience reports · 2022Review
- Crosstalk between Metabolic Disorders and Immune Cells.International journal of molecular sciences · 2021Review
- Adipose Tissue Hypoxia Correlates with Adipokine Hypomethylation and Vascular Dysfunction.Biomedicines · 2021Article
- The Effects of High-Protein Diet and Resistance Training on Glucose Control and Inflammatory Profile of Visceral Adipose Tissue in Rats.Nutrients · 2021Article
- Effect of exercise on peritoneal microenvironment and progression of ovarian cancer.American journal of cancer research · 2021Article
- Article
- Chronic inflammation in psoriasis promotes visceral adiposity associated with noncalcified coronary burden over time.JCI insight · 2020Observational
- Aging with rhythmicity. Is it possible? Physical exercise as a pacemaker.Life sciences · 2020Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visceral adipose tissue is an immunogenic tissue, which turns detrimental during obesity by activation of proinflammatory macrophages. During aging, chronic inflammation increases proportional to visceral adipose tissue (VAT) mass and associates with escalating morbidity and mortality. Here, we utilize a mouse model to investigate the inflammatory status of visceral adipose tissue in lean aging mice and assess the effects of exercise training interventions. We randomized adult (11 months; n = 21) and old (23 months; n = 27) mice to resistance training (RT) or endurance training (ET), or to a sedentary control group (S). Strikingly, we observed an anti-inflammatory phenotype in the old mice, consisting of higher accumulation of M2 macrophages and IL-10 expression, compared to the adult mice. In concordance, old mice also had less VAT mass and smaller adipocytes compared to adult mice. In both age groups, exercise training enhanced the anti-inflammatory phenotype and increased PGC1-α mRNA expression. Intriguingly, the brown adipose tissue marker UCP1 was modestly higher in old mice, while remained unchanged by the intervention. In conclusion, in the absence of obesity, visceral adipose tissue possesses a pronounced anti-inflammatory phenotype during aging which is further enhanced by exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.