ArticleScientific reports2019
Optimal timing of initiating continuous renal replacement therapy in septic shock patients with acute kidney injury.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Timing of renal-replacement therapy in patients with acute kidney injury and sepsis: a systematic review and meta-analysis.BMC nephrology · 2026Pooled it
- Observational studies of early versus late salvage therapies in critical care exhibit intrinsic selection bias: two meta-analyses.Critical care (London, England) · 2025Pooled it
- Factors Associated with In-Hospital Mortality after Continuous Renal Replacement Therapy for Critically Ill Patients: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Optimizing Fluid Management Guided by Volumetric Parameters in Patients with Sepsis and ARDS.International journal of molecular sciences · 2023Trial
- Continuous imputation of blood gas and metabolic panel laboratory values in the intensive care unit using machine learning.Journal of clinical monitoring and computing · 2026Article
- Dynamic Lactate-to-Albumin Ratio Trajectories and Outcomes in Sepsis-Associated Acute Kidney Injury: Evidence From MIMIC-IV and a Multicenter Chinese Cohort.JMIR medical informatics · 2026Observational
- Review
- Outcomes of continuous kidney replacement therapy in pediatric patients: the impact of timing and predictors of mortality.Pediatric nephrology (Berlin, Germany) · 2025Article
- Challenges and Limitations in Utilization of Continuous Renal Replacement Therapies in Public Sector Hospitals-Perspective from India.Kidney international reports · 2025Article
- Article
- Mortality of elderly patients with acute kidney injury undergoing continuous renal replacement therapy: is age a risk factor?Kidney research and clinical practice · 2024Article
- Lactate Profile Assessment-A Good Predictor of Prognosis in Patients with COVID-19 and Septic Shock Requiring Continuous Renal Therapy.Clinics and practice · 2024Article
- Sonography Guided Evaluation of Hemodynamic Indices in Critically Ill Patients Suffering from AKI during CRRT.Tanaffos · 2024Article
- Machine learning prediction models for mortality risk in sepsis-associated acute kidney injury: evaluating early versus late CRRT initiation.Frontiers in medicine · 2024Article
- Interaction of ceftazidime and clindamycin with extracorporeal life support.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2023Article
- Effect of fluid overload on survival in patients with sepsis-induced acute kidney injury receiving continuous renal replacement therapy.Scientific reports · 2023Article
- Article
- Optimal stage of initiating continuous renal replacement therapy in the treatment of neonatal acute kidney injury.Experimental and therapeutic medicine · 2022Article
- Continuous Renal Replacement Therapy in Acute Brain Injury.Frontiers in nephrology · 2022Review
- When and why to start continuous renal replacement therapy in critically ill patients with acute kidney injury.Kidney research and clinical practice · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) in patients with septic shock is associated with high mortality, but the appropriate timing for initiating continuous renal replacement therapy (CRRT) is controversial. We retrospectively enrolled 158 septic shock patients with AKI in the medical intensive care unit (ICU) from July 2016 to April 2018. The time from AKI onset to CRRT initiation was compared according to ICU mortality using Cox proportional hazard, receiver operating characteristic, and Kaplan-Meier survival analyses. At the time of ICU discharge, the mortality rate was 50.6% (n = 80). It took longer to initiate CRRT in non-survivors than in survivors (hazard ratio 1.009; 95% confidence interval [CI] 1.003-1.014; P = 0.002). The cut-off time from AKI onset to CRRT initiation for ICU mortality was 16.5 hours (area under the curve 0.786; 95% CI 0.716-0.856; P < 0.001). The cumulative mortality rate was significantly higher in patients in whom CRRT was initiated beyond 16.5 hours after AKI onset than in those in whom CCRT was initiated within 16.5 hours (log-rank test, P < 0.001). Several clinical situations must be considered to determine the optimal timing of CRRT initiation in these patients. Close observation and CRRT initiation within 16.5 hours after AKI onset may help improve survival.
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