ArticleScientific reports2019
The genetic relationship between female reproductive traits and six psychiatric disorders.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- All in the Family? A Systematic Review and Meta-analysis of Parenting and Family Environment as Risk Factors for Attention-Deficit/Hyperactivity Disorder (ADHD) in Children.Prevention science : the official journal of the Society for Prevention Research · 2024Pooled it
- Identifying causal associations between women's reproductive traits and risk of schizophrenia: a multivariate validated two-sample Mendelian randomization analysis.BMC psychiatry · 2024Pooled it
- Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders.Translational psychiatry · 2023Pooled it
- Genetics of OCD and Related Disorders; Searching for Shared Factors.Current topics in behavioral neurosciences · 2021Pooled it
- Deciphering the shared genetic architecture between female reproductive disorders and psychiatric disorders.Journal of ovarian research · 2026Article
- The emergence of genetic variants linked to brain and cognitive traits in human evolution.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Pitfalls and Strategies for Measuring Menopausal Stage in Eating Disorder Studies of Women in Midlife.The International journal of eating disorders · 2025Article
- Associations between reproductive factors and the prevalence of depression: findings from the National Health and Nutrition Examination Survey (NHANES) 2005-2018.BMC public health · 2024Article
- Causal effect of the age at first birth with depression: a mendelian randomization study.BMC medical genomics · 2024Article
- Causal relationship between Women's reproductive traits andFrontiers in genetics · 2024Article
- Causal associations between female reproductive behaviors and psychiatric disorders: a lifecourse Mendelian randomization study.BMC psychiatry · 2023Article
- Genetic liability to posttraumatic stress disorder and its association with postpartum depression.Psychological medicine · 2023Article
- Review of mendelian randomization studies on age at natural menopause.Frontiers in endocrinology · 2023Review
- Shared genetic basis between reproductive behaviors and anxiety-related disorders.Molecular psychiatry · 2022Article
- The relationships between women's reproductive factors: a Mendelian randomisation analysis.BMC medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Female reproductive behaviours have important implications for evolutionary fitness and health of offspring. Here we used the second release of UK Biobank data (N = 220,685) to evaluate the association between five female reproductive traits and polygenic risk scores (PRS) projected from genome-wide association study summary statistics of six psychiatric disorders (N = 429,178). We found that the PRS of attention-deficit/hyperactivity disorder (ADHD) were strongly associated with age at first birth (AFB) (genetic correlation of -0.68 ± 0.03), age at first sexual intercourse (AFS) (-0.56 ± 0.03), number of live births (NLB) (0.36 ± 0.04) and age at menopause (-0.27 ± 0.04). There were also robustly significant associations between the PRS of eating disorder (ED) and AFB (0.35 ± 0.06), ED and AFS (0.19 ± 0.06), major depressive disorder (MDD) and AFB (-0.27 ± 0.07), MDD and AFS (-0.27 ± 0.03) and schizophrenia and AFS (-0.10 ± 0.03). These associations were mostly explained by pleiotropic effects and there was little evidence of causal relationships. Our findings can potentially help improve reproductive health in women, hence better child outcomes. Our findings also lend partial support to the evolutionary hypothesis that causal mutations underlying psychiatric disorders have positive effects on reproductive success.
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