Evidence map›Paper›PMID 31427504›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Large-scale identification of pathogen essential genes during coinfection with sympatric and allopatric microbes.

Gina R Lewin, Apollo Stacy, Kelly L Michie, Richard J Lamont, Marvin Whiteley

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Review
  2. D-alanine aminotransferase (Dat) promotesbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. The role of colony morphotype in shaping gene essentiality inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Identifying essential genes inJournal of bacteriology · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Essential genes formSystems · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Identification of essential genes inMicrobial genomics · 2023
    Article
  19. Whole-Genome Sequencing Reveals Diversity of Carbapenem-ResistantAntimicrobial agents and chemotherapy · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gina R LewinSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0002-1189-6696
Apollo StacyMetaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
Kelly L MichieSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.
Richard J LamontDepartment of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY 40202.ORCID 0000-0002-3147-5039
Marvin WhiteleySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332; marvin.whiteley@biosci.gatech.edu.

Funding

Probing Polymicrobial Synergy Using hihg Throughout GenomicsR01DE023193 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI LAMONT, RICHARD J, WHITELEY, MARVIN · 2013 to 2023
$4.7M
Metabolite sensing in a polymicrobial infectionR01DE020100 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI WHITELEY, MARVIN · 2011 to 2022
$3.3M
Probing the impact of polymicrobial interactions on the virulence of an oral pathogenF32DE027281 · NIDCR · GEORGIA INSTITUTE OF TECHNOLOGY · PI LEWIN, GINA · 2017 to 2021
$215k
Identifying disease mechanisms of a periodontal pathogenF31DE024931 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI STACY, APOLLO · 2014 to 2016
$119k
NIDCR NIH HHS F31 DE024931NIDCR NIH HHS F32 DE027281NIDCR NIH HHS R01 DE020100NIDCR NIH HHS R01 DE023193
6 · The paper itself

Abstract

Recent evidence suggests that the genes an organism needs to survive in an environment drastically differ when alone or in a community. However, it is not known if there are universal functions that enable microbes to persist in a community and if there are functions specific to interactions between microbes native to the same (sympatric) or different (allopatric) environments. Here, we ask how the essential functions of the oral pathogen

Indexed as

AggregatibacterAggregatibacter actinomycetemcomitansAnimalsCoinfectionGenes, EssentialGenetic FitnessMiceMicrobiotaRNA, Ribosomal, 16SSympatryRNA, Ribosomal, 16SAggregatibacterCoDE genesessentialpolymicrobial

Identifiers

PMID31427504
PMCPMC6765283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.