Evidence map›Paper›PMID 31427449›Full record

ArticleInfection and immunity2019

Intradermal or Sublingual Delivery and Heat-Labile Enterotoxin Proteins Shape Immunologic Responses to a CFA/I Fimbria-Derived Subunit Antigen Vaccine against Enterotoxigenic Escherichia coli.

Milton Maciel, David Bauer, Robin L Baudier, Jacob Bitoun, John D Clements, Steven T Poole, Mark A Smith, Robert W Kaminski, Stephen J Savarino, Elizabeth B Norton

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Milton Maciel *Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
David Bauer *Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Robin L BaudierDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Jacob BitounDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.ORCID 0000-0001-7110-2328
John D ClementsDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Steven T PooleHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Mark A SmithSubunit Enteric Vaccines and Immunology, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Robert W KaminskiSubunit Enteric Vaccines and Immunology, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.ORCID 0000-0002-4015-5694
Stephen J SavarinoEnteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA.
Elizabeth B NortonDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA enorton@tulane.edu.
Tulane University · USHenry M. Jackson Foundation · USWalter Reed Army Institute of Research · USNaval Medical Research Command · US

Funding

Development of Novel Adjuvants LTA and LTA1R01AI114697 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI NORTON, ELIZABETH B · 2015 to 2019
$2.1M
The Role of STa in ETEC PathogenesisR01AI125542 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI BITOUN, JACOB P. · 2017 to 2020
$1.5M
NIAID NIH HHS R01 AI114697NIAID NIH HHS R01 AI125542
6 · The paper itself

Abstract

Enterotoxigenic

Indexed as

Adjuvants, ImmunologicAnimalsAntibodies, BacterialAntigens, BacterialBacterial ToxinsEnterotoxigenic Escherichia coliEnterotoxinsEscherichia coli InfectionsEscherichia coli VaccinesFecesFemaleMiceMice, Inbred BALB CVaccines, SubunitAdjuvants, ImmunologicAntibodies, BacterialAntigens, BacterialBacterial ToxinsEnterotoxinsEscherichia coli VaccinesVaccines, SubunitCFA/IdmLTETECintradermalLTA1sublingualvaccine

Identifiers

PMID31427449
PMCPMC6803349
OpenAlexW2967133601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.