Evidence map›Paper›PMID 31427364›Full record

ArticleImmunoHorizons2019

Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes.

Eric J Wigton, Anthony L DeFranco, K Mark Ansel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ImmunoHorizons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Eric J WigtonSandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143; and.
Anthony L DeFrancoDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143 Anthony.defranco@ucsf.edu mark.ansel@ucsf.edu.ORCID 0000-0002-7938-163X
K Mark AnselSandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143; and Anthony.defranco@ucsf.edu mark.ansel@ucsf.edu.ORCID 0000-0003-4840-9879
University of California, San Francisco · US

Funding

MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
Role of miRNAs in Th2-Driven inflammation in AsthmaR01HL109102 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Karl Mark Ansel · 2011 to 2026
$5.5M
B cell TLRs and germinal centersR21AI117378 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEFRANCO, ANTHONY L · 2015 to 2016
$436k
NHLBI NIH HHS R01 HL109102NIAID NIH HHS R21 AI117378NIAID NIH HHS T32 AI007334
6 · The paper itself

Abstract

The germinal center (GC) is the anatomical site where humoral immunity evolves. B cells undergo cycles of proliferation and selection to produce high-affinity Abs against Ag. Direct linkage of a TLR9 agonist (CpG) to a T-dependent Ag increases the number of GC B cells. We used a T-dependent Ag complexed with CpG and a genetic model for ablating the TLR9 signaling adaptor molecule MyD88 specifically in B cells (B-MyD88

Indexed as

LigandsAnimalsAntigensB-Lymphocytesgamma-GlobulinsGerminal CenterLymphocyte ActivationMechanistic Target of Rapamycin Complex 1MiceMice, TransgenicMyeloid Differentiation Factor 88Proto-Oncogene Proteins c-mycSignal TransductionT-LymphocytesToll-Like Receptor 9TranscriptomeAntigensgamma-GlobulinsLigandsMechanistic Target of Rapamycin Complex 1Myc protein, mouseMyd88 protein, mouseMyeloid Differentiation Factor 88Proto-Oncogene Proteins c-mycTlr9 protein, mouseToll-Like Receptor 9

Identifiers

PMID31427364
PMCPMC6738343
OpenAlexW2969424103

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.