Evidence map›Paper›PMID 31427355›Full record

ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2019

Associations among gastroesophageal reflux disease, mental disorders, sleep and chronic temporomandibular disorder: a case-control study.

Yuanyuan Li, Ming Fang, Lina Niu, Yu Fan, Yan Liu, Yong Long, Xiaodong Liu, Franklin R Tay, Jihua Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Mendel randomization confirmed gastroesophageal reflux disease may increase the risk of mental disorders.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026
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  13. Gastroesophageal reflux disease, temporomandibular disorders and dysfunctional breathing.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yuanyuan LiState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Departments of Prosthodontics (Li, Fang, Niu, Fan, Y. Liu, Long, Tay, Chen), and Oral Anatomy and Physiology (X. Liu), School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Epidemiology, School of Public Health (Long), The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Endodontics (Tay, Chen), The Dental College of Georgia, Augusta University, Augusta, Ga.
Ming FangState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Departments of Prosthodontics (Li, Fang, Niu, Fan, Y. Liu, Long, Tay, Chen), and Oral Anatomy and Physiology (X. Liu), School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Epidemiology, School of Public Health (Long), The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Endodontics (Tay, Chen), The Dental College of Georgia, Augusta University, Augusta, Ga.
Lina NiuState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Departments of Prosthodontics (Li, Fang, Niu, Fan, Y. Liu, Long, Tay, Chen), and Oral Anatomy and Physiology (X. Liu), School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Epidemiology, School of Public Health (Long), The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Endodontics (Tay, Chen), The Dental College of Georgia, Augusta University, Augusta, Ga.
Yu FanState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Departments of Prosthodontics (Li, Fang, Niu, Fan, Y. Liu, Long, Tay, Chen), and Oral Anatomy and Physiology (X. Liu), School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Epidemiology, School of Public Health (Long), The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Endodontics (Tay, Chen), The Dental College of Georgia, Augusta University, Augusta, Ga.
Yan LiuState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Departments of Prosthodontics (Li, Fang, Niu, Fan, Y. Liu, Long, Tay, Chen), and Oral Anatomy and Physiology (X. Liu), School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Epidemiology, School of Public Health (Long), The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Endodontics (Tay, Chen), The Dental College of Georgia, Augusta University, Augusta, Ga.
Yong LongState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Departments of Prosthodontics (Li, Fang, Niu, Fan, Y. Liu, Long, Tay, Chen), and Oral Anatomy and Physiology (X. Liu), School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Epidemiology, School of Public Health (Long), The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Endodontics (Tay, Chen), The Dental College of Georgia, Augusta University, Augusta, Ga.
Xiaodong LiuState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Departments of Prosthodontics (Li, Fang, Niu, Fan, Y. Liu, Long, Tay, Chen), and Oral Anatomy and Physiology (X. Liu), School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Epidemiology, School of Public Health (Long), The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Endodontics (Tay, Chen), The Dental College of Georgia, Augusta University, Augusta, Ga.
Franklin R TayState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Departments of Prosthodontics (Li, Fang, Niu, Fan, Y. Liu, Long, Tay, Chen), and Oral Anatomy and Physiology (X. Liu), School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Epidemiology, School of Public Health (Long), The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Endodontics (Tay, Chen), The Dental College of Georgia, Augusta University, Augusta, Ga.
Jihua ChenState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Departments of Prosthodontics (Li, Fang, Niu, Fan, Y. Liu, Long, Tay, Chen), and Oral Anatomy and Physiology (X. Liu), School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Epidemiology, School of Public Health (Long), The Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Endodontics (Tay, Chen), The Dental College of Georgia, Augusta University, Augusta, Ga. jhchen@fmmu.edu.cn ftay@augusta.edu xdliu@fmmu.edu.cn.
Air Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTemporomandibular disorders (TMDs) are a family of pain-related disorders associated with impaired function in the jaw, temporomandibular joint and muscles of mastication. Our objectives were to evaluate the association between chronic TMD and gastresophageal reflux disease (GERD) and to determine whether mental disorders or undermined sleep mediates this association.

methodsWe conducted a case-control study involving 1522 consecutive adult patients with chronic TMD and 1522 matched controls from 2 hospitals in China. All participants were aged between 18 and 70 years and were recruited from July 2017 to April 2018 Chronic TMD was diagnosed by trained dentists using the criteria in the Orofacial Pain Prospective Evaluation and Risk Assessment Study. Trained gastroenterologists made blinded diagnoses of GERD according to the Montreal definition and classification (at least 2 d of mild symptoms, or 1 d of moderate or severe symptoms per week). We used validated questionnaires to evaluate psychological status and sleep quality.

resultsOf the study participants, we identified 132 patients and 61 controls with GERD. Using conditional logistic regression analysis, we identified GERD as a risk factor for TMD (odds ratio 2.74, 95% confidence interval 1.88 to 3.98). Mediation analyses identified that somatization, anxiety and undermined sleep moderately mediated the relation between TMD and GERD.

interpretationOur study suggests that symptomatic GERD is associated with chronic, painful TMD, and somatization, anxiety and undermined sleep mediate this association to a certain extent. Due consideration should be given to the evaluation and management of gastrointestinal symptoms and mental disorders in the combined therapy for painful TMD.

Indexed as

AdolescentAdultAgedCase-Control StudiesChronic DiseaseFemaleGastroesophageal RefluxHumansMaleMental DisordersMiddle AgedRisk FactorsSleep Wake DisordersTemporomandibular Joint DisordersYoung Adult

Identifiers

PMID31427355
PMCPMC6699946
OpenAlexW2968752926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.