Observational studyBMJ open2019
Changing incidence of reported viral hepatitis in China from 2004 to 2016: an observational study.
Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- Expanding hepatitis C virus test uptake using self-testing among men who have sex with men in China: two parallel randomized controlled trials.BMC medicine · 2023Trial
- Hepatitis B in China: the analysis of mortality and burden of disease trends from 2008 to 2021.BMC public health · 2026Article
- Changes in the incidence of notifiable infectious diseases before, during, and after the COVID-19 pandemic in Mainland China.BMC infectious diseases · 2025Article
- Curative care expenditure across different comorbidity states of chronic hepatitis B: a prevalence study in Sichuan Province, China.BMJ open · 2025Article
- Trends in Mortality Related to Hepatitis B and C from 1990 to 2019 in the Western Pacific Region.Gut and liver · 2024Article
- Mortality Burden of Liver Cancer in China: An Observational Study From 2008 to 2020.Journal of clinical and translational hepatology · 2024Article
- Trends in Mortality of Cirrhosis in China: An Analysis of the China Death Surveillance Database from 2008 to 2020.Journal of clinical and translational hepatology · 2024Article
- The Shifting Epidemiology of Hepatitis A in the World Health Organization Western Pacific Region.Vaccines · 2024Review
- Positive association between insulin resistance and fatty liver disease in psoriasis: evidence from a cross-sectional study.Frontiers in immunology · 2024Article
- The epidemiological characteristics of liver disease in hospitalized children: a 10-year single-center retrospective study.Frontiers in pediatrics · 2024Article
- Trends in sexually transmitted and blood-borne infections in China from 2005 to 2021: a joinpoint regression model.BMC infectious diseases · 2023Article
- Impact of urbanization on morbidity of hepatitis A: a national panel study in China during 2005-2018.Infectious diseases of poverty · 2023Article
- Cancer statistics in Chinese older people, 2022: current burden, time trends, and comparisons with the US, Japan, and the Republic of Korea.Science China. Life sciences · 2023Article
- Changing incidence of hepatitis B and persistent infection risk in adults: a population-based follow-up study from 2011 in China.BMC public health · 2023Article
- Trends in respiratory diseases before and after the COVID-19 pandemic in China from 2010 to 2021.BMC public health · 2023Article
- Analysis of the spatial-temporal distribution characteristics of hepatitis E in Jiangsu province from 2005 to 2020.Frontiers in public health · 2023Article
- Elimination of hepatitis C in a hospital characterized by infectious diseases.Frontiers in public health · 2023Article
- Trends in hepatitis B notification rates in Guangzhou, China, between 2009 and 2020: an epidemiological study.BMC infectious diseases · 2022Article
- Regional differences and temporal trend analysis of Hepatitis B in Brazil.BMC public health · 2022Article
- HCV 6a was expanding and became the predominant subtype among blood donors between 2004 and 2019 in Guangdong, China.Virologica Sinica · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveChina's national hepatitis burden is high. This study aims to provide a detailed national-level description of the reported incidence of viral hepatitis in China during 2004-2016.
designObservational study.
settingData were obtained from China's National Notifiable Disease Reporting System, and changing trends were estimated by joinpoint regression analysis.
participantsIn this system, 16 927 233 reported viral hepatitis cases occurring during 2004-2016 were identified. PRIMARY OUTCOME MEASURE: Incidence rates per 100 000 person-years and changing trends were calculated.
resultsThere were 16 927 233 new cases of viral hepatitis reported in China from 2004 to 2016. Hepatitis B (HBV) (n=13 543 137, 80.00%) and hepatitis C (HCV) (n=1 844 882, 10.90%) accounted for >90% of the cases. The overall annual percent change (APC) in reported cases of viral hepatitis and HBV were 0.3%(95% CI -2.0 to 0.8, p=0.6) and -0.2% (95% CI -1.6 to 1.2, p=0.8), respectively, showing a stable trend. HBV rates were highest in the 20-29 year old age group and lowest in younger individuals, likely resulting from the universal HBV vaccination. The reported incidence of HCV and hepatitis E (HEV) showed increasing trends; the APCs were 14.5% (95% CI 13.1 to 15.9, p<0.05) and 4.7% (95% CI 2.8 to 6.7, p<0.05), respectively. The hepatitis A (HAV) reporting incidence decreased, and the APC was -13.1% (95% CI -15.1 to -11.0, p<0.05). There were marked differences in the reporting of hepatitis among provinces.
conclusionsHBV continues to constitute the majority of viral hepatitis cases in China. Over the entire study period, the HBV reporting incidence was stable, the HCV and HEV incidence increased and the HAV incidence decreased. There were significant interprovincial disparities in the burden of viral hepatitis, with higher rates in economically less-developed areas. Vaccination is important for viral hepatitis prevention and control.
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