Evidence map›Paper›PMID 31427298›Full record

ArticleAntimicrobial agents and chemotherapy2019

Extremely Low Hit Rate in a Diverse Chemical Drug Screen Targeting Mycobacterium abscessus.

Jakob J Malin, Sandra Winter, Edeltraud van Gumpel, Georg Plum, Jan Rybniker

Abstract readLetter
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Antimicrobial and Antibiofilm Effects of Bithionol againstAntibiotics (Basel, Switzerland) · 2024
    Article
  5. Exploring antibiotic resistance mechanisms inFrontiers in microbiology · 2024
    Review
  6. Article
  7. Article
  8. Why Matter Matters: Fast-TrackingMolecules (Basel, Switzerland) · 2022
    Review
  9. Mycobacterium abscessus drug discovery using machine learning.Tuberculosis (Edinburgh, Scotland) · 2022
    Article
  10. Article
  11. Article
  12. Rifabutin Is Inactivated by Mycobacterium abscessus Arr.Antimicrobial agents and chemotherapy · 2021
    Article
  13. Review
  14. Etamycin as a NovelInternational journal of molecular sciences · 2020
    Article
  15. Thiostrepton: A Novel Therapeutic Drug Candidate forMolecules (Basel, Switzerland) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jakob J MalinDepartment I of Internal Medicine, Division of Infectious Diseases, University of Cologne, Cologne, Germany.
Sandra WinterDepartment I of Internal Medicine, Division of Infectious Diseases, University of Cologne, Cologne, Germany.
Edeltraud van GumpelDepartment I of Internal Medicine, Division of Infectious Diseases, University of Cologne, Cologne, Germany.
Georg PlumFaculty of Medicine and University Hospital of Cologne, Institute for Medical Microbiology, Immunology, and Hygiene, University of Cologne, Cologne, Germany.
Jan RybnikerDepartment I of Internal Medicine, Division of Infectious Diseases, University of Cologne, Cologne, Germany jan.rybniker@uk-koeln.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial AgentsCell Line, TumorDrug Delivery SystemsDrug Evaluation, PreclinicalHep G2 CellsHumansMicrobial Sensitivity TestsMycobacterium abscessusMycobacterium Infections, NontuberculousMycobacterium tuberculosisNontuberculous MycobacteriaAnti-Bacterial Agentsdrug discoverydrug screeningemerging pathogenshit rateMycobacterium abscessusNTM

Identifiers

PMID31427298
PMCPMC6811439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.