Evidence map›Paper›PMID 31427293›Full record

ArticleAntimicrobial agents and chemotherapy2019

Validating the AMRFinder Tool and Resistance Gene Database by Using Antimicrobial Resistance Genotype-Phenotype Correlations in a Collection of Isolates.

Michael Feldgarden, Vyacheslav Brover, Daniel H Haft, Arjun B Prasad, Douglas J Slotta, Igor Tolstoy, Gregory H Tyson, Shaohua Zhao, Chih-Hao Hsu, Patrick F McDermott and 7 more

Erratum issuedAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 885 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
885citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

885 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. ElevatedEmerging microbes & infections · 2026
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  6. First Report of blaMicrobiologyOpen · 2026
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  11. Antimicrobial Resistance and Virulence ofAntibiotics (Basel, Switzerland) · 2026
    Article
  12. Review
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  17. Article
  18. Article
  19. Intraspecific diversity ofMicrobiology spectrum · 2026
    Article
  20. Fluoroquinolone-resistantMicrobiology spectrum · 2026
    Article

825 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Michael FeldgardenNational Center for Biological Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA michael.feldgarden@nih.gov.
Vyacheslav BroverNational Center for Biological Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Daniel H HaftNational Center for Biological Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Arjun B PrasadNational Center for Biological Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Douglas J SlottaNational Center for Biological Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Igor TolstoyNational Center for Biological Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Gregory H TysonFood and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland, USA.
Shaohua ZhaoFood and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland, USA.
Chih-Hao HsuFood and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland, USA.
Patrick F McDermottFood and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland, USA.
Daniel A TadesseFood and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland, USA.
Cesar MoralesUSDA Food Safety and Inspection Service, Office of Public Health Science, Eastern Laboratory, Athens, Georgia, USA.
Mustafa SimmonsUSDA Food Safety and Inspection Service, Office of Public Health Science, Eastern Laboratory, Athens, Georgia, USA.
Glenn TillmanUSDA Food Safety and Inspection Service, Office of Public Health Science, Eastern Laboratory, Athens, Georgia, USA.
Jamie WasilenkoUSDA Food Safety and Inspection Service, Office of Public Health Science, Eastern Laboratory, Athens, Georgia, USA.
Jason P FolsterEnteric Diseases Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
William KlimkeNational Center for Biological Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance (AMR) is a major public health problem that requires publicly available tools for rapid analysis. To identify AMR genes in whole-genome sequences, the National Center for Biotechnology Information (NCBI) has produced AMRFinder, a tool that identifies AMR genes using a high-quality curated AMR gene reference database. The Bacterial Antimicrobial Resistance Reference Gene Database consists of up-to-date gene nomenclature, a set of hidden Markov models (HMMs), and a curated protein family hierarchy. Currently, it contains 4,579 antimicrobial resistance proteins and more than 560 HMMs. Here, we describe AMRFinder and its associated database. To assess the predictive ability of AMRFinder, we measured the consistency between predicted AMR genotypes from AMRFinder and resistance phenotypes of 6,242 isolates from the National Antimicrobial Resistance Monitoring System (NARMS). This included 5,425

Indexed as

analytical softwareantimicrobial resistanceCampylobactercomputational biologydatabasefoodborne pathogensgenomicsSalmonellasurveillance

Identifiers

PMID31427293
PMCPMC6811410

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.