Evidence map›Paper›PMID 31427288›Full record

ArticleDevelopment (Cambridge, England)2019

H3K27me3-mediated silencing of structural genes is required for zebrafish heart regeneration.

Raz Ben-Yair, Vincent L Butty, Michele Busby, Yutong Qiu, Stuart S Levine, Alon Goren, Laurie A Boyer, C Geoffrey Burns, Caroline E Burns

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Raz Ben-YairCardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Vincent L ButtyDepartments of Biology and Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Michele BusbyThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-1731-288X
Yutong QiuDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Stuart S LevineDepartments of Biology and Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Alon GorenThe Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA agoren@ucsd.edu lboyer@mit.edu geoff.burns@childrens.harvard.edu caroline.burns@childrens.harvard.edu.ORCID 0000-0001-5669-9357
Laurie A BoyerDepartments of Biology and Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA agoren@ucsd.edu lboyer@mit.edu geoff.burns@childrens.harvard.edu caroline.burns@childrens.harvard.edu.ORCID 0000-0003-3491-4962
C Geoffrey BurnsCardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA agoren@ucsd.edu lboyer@mit.edu geoff.burns@childrens.harvard.edu caroline.burns@childrens.harvard.edu.ORCID 0000-0002-5812-6621
Caroline E BurnsCardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA agoren@ucsd.edu lboyer@mit.edu geoff.burns@childrens.harvard.edu caroline.burns@childrens.harvard.edu.ORCID 0000-0003-1565-7489
Massachusetts Institute of Technology · USBoston Children's Hospital · USBroad Institute · USHarvard University · USUniversity of California San Diego · US

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MATTHEW G. VANDER HEIDEN · 1985 to 2026
$93.9M
Change of InstitutionR35HL135831 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BURNS, CAROLINE E · 2017 to 2023
$4.2M
Investigating the role of H2A.Z dynamics in regulating cardiac lineage commitmentR01HL140471 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYER, LAURIE A · 2018 to 2021
$2.2M
Modeling thoracic aortic aneurysm in zebrafishR01HL139806 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BURNS, C. GEOFFREY · 2018 to 2021
$1.7M
Deciphering the role of Notch signaling in zebrafish heart regenerationR01HL127067 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BURNS, C. GEOFFREY, BURNS, CAROLINE E · 2015 to 2018
$1.7M
NCI NIH HHS P30 CA014051NHLBI NIH HHS R01 HL127067NHLBI NIH HHS R01 HL139806NHLBI NIH HHS R01 HL140471NHLBI NIH HHS R35 HL135831
6 · The paper itself

Abstract

Deciphering the genetic and epigenetic regulation of cardiomyocyte proliferation in organisms that are capable of robust cardiac renewal, such as zebrafish, represents an attractive inroad towards regenerating the human heart. Using integrated high-throughput transcriptional and chromatin analyses, we have identified a strong association between H3K27me3 deposition and reduced sarcomere and cytoskeletal gene expression in proliferative cardiomyocytes following cardiac injury in zebrafish. To move beyond an association, we generated an inducible transgenic strain expressing a mutant version of histone 3, H3.3

Indexed as

Gene SilencingAnimalsCell ProliferationCytokinesisCytoskeletonGene Expression Regulation, DevelopmentalHeartHistonesLysineMethylationMyocytes, CardiacRegenerationSarcomeresZebrafishHistonesLysineCardiomyocyteCardiovascularChromatinEpigeneticH3K27me3Heart regenerationProliferationZebrafish

Identifiers

PMID31427288
PMCPMC6803378
OpenAlexW2971764921

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.