Evidence map›Paper›PMID 31427287›Full record

ArticleDevelopment (Cambridge, England)2019

Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse.

Charlotte Chaimowicz, Pierre-Louis Ruffault, Cyril Chéret, Andrew Woehler, Niccolò Zampieri, Gilles Fortin, Alistair N Garratt, Carmen Birchmeier

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Charlotte ChaimowiczDevelopmental Biology/Signal Transduction, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Society, 13125 Berlin, Germany.ORCID 0000-0002-5998-7482
Pierre-Louis RuffaultDevelopmental Biology/Signal Transduction, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Society, 13125 Berlin, Germany.ORCID 0000-0002-3378-3828
Cyril ChéretDevelopmental Biology/Signal Transduction, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Society, 13125 Berlin, Germany.
Andrew WoehlerSystems Biology Imaging, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Society, 13125 Berlin, Germany.ORCID 0000-0001-5157-9313
Niccolò ZampieriDevelopment and Function of Neural Circuits, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Society, 13125 Berlin, Germany.ORCID 0000-0002-2228-9453
Gilles FortinUMR9197, CNRS/Université Paris-Sud, Paris-Saclay Institute of Neuroscience, 1 Avenue de la Terrasse, 91190 Gif-sur-Yvette, France.ORCID 0000-0002-2123-8603
Alistair N GarrattInstitute of Cell Biology and Neurobiology, Charité-Universitätsmedizin Berlin, Virchowweg 6, 10117 Berlin, Germany.ORCID 0000-0001-9631-3041
Carmen BirchmeierDevelopmental Biology/Signal Transduction, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Society, 13125 Berlin, Germany cbirch@mdc-berlin.de.ORCID 0000-0002-2041-8872

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feeding and breathing are essential motor functions and rely on the activity of hypoglossal and phrenic motor neurons that innervate the tongue and diaphragm, respectively. Little is known about the genetic programs that control the development of these neuronal subtypes. The transcription factor Tshz1 is strongly and persistently expressed in developing hypoglossal and phrenic motor neurons. We used conditional mutation of

Indexed as

AnimalsAnimals, NewbornApoptosisbcl-2-Associated X ProteinCell SurvivalDiaphragmHomeodomain ProteinsHypoglossal NerveMiceMice, TransgenicMotor NeuronsMutationPhrenic NervePlethysmographyRepressor ProteinsRespirationBax protein, mousebcl-2-Associated X ProteinHomeodomain ProteinsRepressor ProteinsTshz1 protein, mouseAerophagiaBreathingHypoglossal nucleusMotor neuronsMousePhrenic motor columnTshz1

Identifiers

PMID31427287
PMCPMC6765129

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.