Evidence map›Paper›PMID 31427143›Full record

ArticleGynecologic oncology2019

Recurrence, death, and secondary malignancy after ovarian conservation for young women with early-stage low-grade endometrial cancer.

Koji Matsuo, James C Cripe, Katherine C Kurnit, Michiko Kaneda, Audrey S Garneau, Gretchen E Glaser, Aaron Nizam, Rachel M Schillinger, Michelle L Kuznicki, Akira Yabuno and 42 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Gynecologic oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Molecular and pathologic data to guide selection of patients with endometrioid endometrial cancer for ovarian preservation.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2024
    Article
  5. Article
  6. Article
  7. Demographic shifts associated with implementation of evidence-based guidelines for ovarian conservation in patients with endometrioid endometrial cancer.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2022
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

52 authors.

Koji MatsuoDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA. Electronic address: koji.matsuo@med.usc.edu.
James C CripeDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
Katherine C KurnitDepartment of Gynecologic Oncology and Reproductive Medicine, MD-Anderson Cancer Center, University of Texas, Houston, TX, USA.
Michiko KanedaDepartment of Gynecology, Hyogo Cancer Center, Hyogo, Japan.
Audrey S GarneauDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky, Lexington, KY, USA.
Gretchen E GlaserDivision of Gynecologic Oncology, Department of Surgery, Mayo Clinic, Rochester, MN, USA.
Aaron NizamDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Long Island, NY, USA.
Rachel M SchillingerGynecologic Oncology Center, Mercy Medical Center, Baltimore, MD, USA.
Michelle L KuznickiDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Moffitt Cancer Center, University of South Florida, FL, USA.
Akira YabunoDepartment of Gynecologic Oncology, Saitama Medical University International Medical Center, Saitama, Japan.
Shiori YanaiDepartment of Obstetrics and Gynecology, Kurashiki Medical Center, Okayama, Japan.
Denise M GarofaloDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado, Denver, CO, USA.
Jiro SuzukiDepartment of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan.
Jessica D St LaurentDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ting-Tai YenDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Johns Hopkins Medicine, Baltimore, MD, USA.
Annie Y LiuDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Masako ShidaDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa, Japan.
Mamoru KakudaDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.
Tetsuro OishiDepartment of Obstetrics and Gynecology, Tottori University School of Medicine, Tottori, Japan.
Shin NishioDepartment of Obstetrics and Gynecology, Kurume University School of Medicine, Fukuoka, Japan.
Jenna Z MarcusDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Rutgers New Jersey Medical School, Newark, NJ, USA.
Sosuke AdachiDepartment of Obstetrics and Gynecology, Niigata University School of Medicine, Niigata, Japan.
Tetsuji KurokawaDepartment of Obstetrics and Gynecology, University of Fukui School of Medicine, Fukui, Japan.
Malcolm S RossDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, PA, USA.
Max P HorowitzDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH, USA.
Marian S JohnsonDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky, Lexington, KY, USA.
Min K KimGynecologic Oncology Center, Mercy Medical Center, Baltimore, MD, USA.
Alexander MelamedDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Karime K MachadoDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Johns Hopkins Medicine, Baltimore, MD, USA.
Kosuke YoshiharaDepartment of Obstetrics and Gynecology, Niigata University School of Medicine, Niigata, Japan.
Yoshio YoshidaDepartment of Obstetrics and Gynecology, University of Fukui School of Medicine, Fukui, Japan.
Takayuki EnomotoDepartment of Obstetrics and Gynecology, Niigata University School of Medicine, Niigata, Japan.
Kimio UshijimaDepartment of Obstetrics and Gynecology, Kurume University School of Medicine, Fukuoka, Japan.
Shinya SatohDepartment of Obstetrics and Gynecology, Tottori University School of Medicine, Tottori, Japan.
Yutaka UedaDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.
Mikio MikamiDepartment of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa, Japan.
Bobbie J RimelDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Rebecca L StoneDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Johns Hopkins Medicine, Baltimore, MD, USA.
Whitfield B GrowdonDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Aikou OkamotoDepartment of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan.
Saketh R GuntupalliDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado, Denver, CO, USA.
Kosei HasegawaDepartment of Gynecologic Oncology, Saitama Medical University International Medical Center, Saitama, Japan.
Mian M K ShahzadDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Moffitt Cancer Center, University of South Florida, FL, USA.
Dwight D ImGynecologic Oncology Center, Mercy Medical Center, Baltimore, MD, USA.
Marina FrimerDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Long Island, NY, USA.
Bobbie S GostoutDivision of Gynecologic Oncology, Department of Surgery, Mayo Clinic, Rochester, MN, USA.
Frederick R UelandDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky, Lexington, KY, USA.
Shoji NagaoDepartment of Gynecology, Hyogo Cancer Center, Hyogo, Japan.
Pamela T SolimanDepartment of Gynecologic Oncology and Reproductive Medicine, MD-Anderson Cancer Center, University of Texas, Houston, TX, USA.
Premal H ThakerDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
Jason D WrightDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Lynda D RomanDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA.

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
NCI NIH HHS P30 CA014089
6 · The paper itself

Abstract

objectiveTo examine the association between ovarian conservation and oncologic outcome in surgically-treated young women with early-stage, low-grade endometrial cancer.

methodsThis multicenter retrospective study examined women aged <50 with stage I grade 1-2 endometrioid endometrial cancer who underwent primary surgery with hysterectomy from 2000 to 2014 (US cohort n = 1196, and Japan cohort n = 495). Recurrence patterns, survival, and the presence of a metachronous secondary malignancy were assessed based on ovarian conservation versus oophorectomy.

resultsDuring the study period, the ovarian conservation rate significantly increased in the US cohort from 5.4% to 16.4% (P = 0.020) whereas the rate was unchanged in the Japan cohort (6.3-8.7%, P = 0.787). In the US cohort, ovarian conservation was not associated with disease-free survival (hazard ratio [HR] 0.829, 95% confidence interval [CI] 0.188-3.663, P = 0.805), overall survival (HR not estimated, P = 0.981), or metachronous secondary malignancy (HR 1.787, 95% CI 0.603-5.295, P = 0.295). In the Japan cohort, ovarian conservation was associated with decreased disease-free survival (HR 5.214, 95% CI 1.557-17.464, P = 0.007) and an increased risk of a metachronous secondary malignancy, particularly ovarian cancer (HR 7.119, 95% CI 1.349-37.554, P = 0.021), but was not associated with overall survival (HR not estimated, P = 0.987). Ovarian recurrence or metachronous secondary ovarian cancer occurred after a median time of 5.9 years, and all cases were salvaged.

conclusionOur study suggests that adoption of ovarian conservation in young women with early-stage low-grade endometrial cancer varies by population. Ovarian conservation for young women with early-stage, low-grade endometrial cancer may be potentially associated with increased risks of ovarian recurrence or metachronous secondary ovarian cancer in certain populations; nevertheless, ovarian conservation did not negatively impact overall survival.

Indexed as

AdultCarcinoma, EndometrioidCohort StudiesDisease-Free SurvivalEndometrial NeoplasmsFemaleHumansHysterectomyJapanNeoplasm GradingNeoplasms, Second PrimaryOrgan Sparing TreatmentsOvaryRetrospective StudiesUnited StatesEndometrial cancerOvarian conservationRecurrenceSecondary primary cancerSurvival

Identifiers

PMID31427143
PMCPMC7537353

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.