Evidence map›Paper›PMID 31427096›Full record

ArticleThe Journal of pediatrics2019

Gastrostomy Tube Feeding in Extremely Low Birthweight Infants: Frequency, Associated Comorbidities, and Long-term Outcomes.

Mollie G Warren, Barbara Do, Abhik Das, P Brian Smith, Ira Adams-Chapman, Sudarshan Jadcherla, Erik A Jensen, Ricki F Goldstein, Ronald N Goldberg, C Michael Cotten and 3 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in The Journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00063063 (Generic Database), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00063063 recruitingnot on this map

Generic Database: A Survey of Morbidity and Mortality in Very Low Birth Weight Infants

TypeobservationalSponsorNICHD Neonatal Research NetworkRan1987 to 2030Enrolled80,000ConditionsInfant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, PrematureArmsNo Intervention
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 47 citations in OpenAlex.

  1. Incidence and factors associated with dysphagia in infants born very preterm or very low birth weight.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  2. Observational
  3. Article
  4. Article
  5. Feeding outcomes of preterm infants discharged with feeding tubes.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  6. Review
  7. Demographic and clinical predictors and inter-center variability of tube feeding in preterm NICU patients.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  8. Method of home tube feeding and 2-3-year neurodevelopmental outcome.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  9. Article
  10. Article
  11. Enteral tube feeding selection at NICU discharge and resource utilization.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Article
  12. Article
  13. Morbidity and mortality in neonates with Down Syndrome based on gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Bronchopulmonary Dysplasia: Then, Now, and Next.Pediatric allergy, immunology, and pulmonology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Mollie G WarrenDepartment of Pediatrics, Duke University, Durham, NC. Electronic address: mollie.warren@duke.edu.
Barbara DoSocial, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD.
Abhik DasSocial, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD.
P Brian SmithDepartment of Pediatrics, Duke University, Durham, NC.
Ira Adams-ChapmanEmory University School of Medicine, Department of Pediatrics, Children's Healthcare of Atlanta, Atlanta, GA.
Sudarshan JadcherlaDepartment of Pediatrics, Nationwide Children's Hospital, Columbus, OH.
Erik A JensenDepartment of Pediatrics, The Children's Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, PA.
Ricki F GoldsteinDepartment of Pediatrics, Duke University, Durham, NC.
Ronald N GoldbergDepartment of Pediatrics, Duke University, Durham, NC.
C Michael CottenDepartment of Pediatrics, Duke University, Durham, NC.
Edward F BellDepartment of Pediatrics, University of Iowa, Iowa City, IA.
William F MalcolmDepartment of Pediatrics, Duke University, Durham, NC.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Duke University · USRTI International · USEmory University · USNationwide Children's Hospital · USUniversity of Iowa · USChildren's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Neonatal Research Network Data Coordinating Center (DCC) 2023-2028U24HD095254 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Abhik Das · 2018 to 2026
$70.2M
Neonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3M
WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 1992 to 2010
$35.2M
XOLAIR IN SUBJECTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS WITH FOOD ALLERGYM01RR000070 · NCRR · STANFORD UNIVERSITY · PI RASGON, NATALIE L · 1985 to 2008
$32.4M
ZUNI KIDNEY PROJECT STUDY I--POPULATION BASED SURVEY OF RENAL DISEASEM01RR000997 · NCRR · UNIVERSITY OF NEW MEXICO · PI ROLDAN, CARLOS A · 1985 to 2010
$30.0M
ZOSUQUIDAR TRIHYDROCHLORIDE DURING CONVENTIONAL INDUCTION AND POST-REMISSIONM01RR000750 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI RODRIGUEZ, HENRY · 1985 to 2008
$25.5M
Zosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DAVIS, PAMELA B · 1985 to 2007
$22.2M
VIRAL DAMAGE TO BRAIN AND NEUROMUSCULAR SYSTEMM01RR000064 · NCRR · UNIVERSITY OF UTAH · PI SWOBODA, KATHRYN J. · 1985 to 2008
$21.7M
X LINKED NYSTAGMUS SYNDROME WITH FEATURES OF ALBINISMM01RR000039 · NCRR · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 1985 to 2007
$21.3M
XU 40468 IN HYPERCHOLESTEROLEMIAM01RR000633 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 1985 to 2007
$21.0M
VITAMIN K DEFICIENCY IN CHOLESTATIC LIVER DISEASEM01RR008084 · NCRR · CINCINNATI CHILDRENS HOSP MED CTR · PI HEUBI, JAMES E. · 1994 to 2009
$20.6M
XOMAZYME-CD5 PLUS THERAPY IN RHEUMATOID ARTHRITISM01RR000030 · NCRR · DUKE UNIVERSITY · PI WILLIAMS, R SANDERS · 1985 to 2006
$20.0M
NCATS NIH HHS UL1 TR000042NCRR NIH HHS M01 RR000030NCRR NIH HHS M01 RR000039NCRR NIH HHS M01 RR000064NCRR NIH HHS M01 RR000070NCRR NIH HHS M01 RR000080NCRR NIH HHS M01 RR000633NCRR NIH HHS M01 RR000750NCRR NIH HHS M01 RR000997NCRR NIH HHS M01 RR007122NCRR NIH HHS M01 RR008084NCRR NIH HHS M01 RR016587NCRR NIH HHS UL1 RR025764NHLBI NIH HHS K23 HL136843NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD021397NICHD NIH HHS U10 HD027871NICHD NIH HHS U10 HD036790NICHD NIH HHS U10 HD040461NICHD NIH HHS U10 HD040498NICHD NIH HHS U10 HD040521NICHD NIH HHS U10 HD053109NICHD NIH HHS U10 HD053119NICHD NIH HHS U10 HD053124NICHD NIH HHS U10 HD068263NICHD NIH HHS U24 HD095254NICHD NIH HHS UG1 HD021364NICHD NIH HHS UG1 HD021385NICHD NIH HHS UG1 HD027851NICHD NIH HHS UG1 HD027853NICHD NIH HHS UG1 HD027856NICHD NIH HHS UG1 HD027880NICHD NIH HHS UG1 HD027904NICHD NIH HHS UG1 HD034216NICHD NIH HHS UG1 HD040492NICHD NIH HHS UG1 HD040689NICHD NIH HHS UG1 HD053089NICHD NIH HHS UG1 HD053109NICHD NIH HHS UG1 HD068244NICHD NIH HHS UG1 HD068263NICHD NIH HHS UG1 HD068270NICHD NIH HHS UG1 HD068278NICHD NIH HHS UG1 HD068284NICHD NIH HHS UG1 HD087226NICHD NIH HHS UG1 HD087229
6 · The paper itself

Abstract

objectiveTo assess the frequency of gastrostomy tube (GT) placement in extremely low birth weight (ELBW) infants, associated comorbidities, and long-term outcomes. STUDY

designAnalysis of ELBW infants from 25 centers enrolled in the National Institute of Child Health and Human Development Neonatal Research Network's Generic Database and Follow-up Registry from 2006 to 2012. Frequency of GT placement before 18-22 months, demographic and medical factors associated with GT placement, and associated long-term outcomes at 18-22 months of corrected age were described. Associations between GT placement and neonatal morbidities and long-term outcomes were assessed with logistic regression after adjustment for center and common co-variables.

resultsOf the 4549 ELBW infants included in these analyses, 333 (7.3%) underwent GT placement; 76% had the GT placed postdischarge. Of infants with GTs, 11% had birth weights small for gestational age, 77% had bronchopulmonary dysplasia, and 29% severe intraventricular hemorrhage or periventricular leukomalacia. At follow-up, 56% of infants with a GT had weight <10th percentile, 61% had neurodevelopmental impairment (NDI), and 55% had chronic breathing problems. After adjustment, small for gestational age, bronchopulmonary dysplasia, intraventricular hemorrhage/periventricular leukomalacia, poor growth, and NDI were associated with GT placement. Thirty-two percent of infants with GTs placed were taking full oral feeds at follow-up.

conclusionsGT placement is common in ELBW infants, particularly among those with severe neonatal morbidities. GT placement in this population was associated with poor growth, NDI, and chronic respiratory and feeding problems at follow-up. The frequency of GT placement postneonatal discharge indicates the need for close nutritional follow-up of ELBW infants.

trial registrationClinicalTrials.gov: NCT00063063.

Indexed as

Infant, Extremely Low Birth WeightChild DevelopmentComorbidityDatabases, FactualEnteral NutritionFemaleFollow-Up StudiesGastrostomyHumansInfantInfant, NewbornInfant, PrematureInfant, Premature, DiseasesMalePractice Patterns, Physicians'RegistriesBayley Scales of Infant developmentbronchopulmonary dysplasiacognitive delaydevelopmentdysfunctional feedingdysphagiafeeding difficultyfollow upgrowthlanguage delaynasogastric tubeneonatalneurodevelopmental impairmentpatent ductus arteriosusperiventricular leukomalaciasevere intraventricular hemorrhagesmall for gestational agesupplemental feeding

Identifiers

PMID31427096
PMCPMC6815700
OpenAlexW2969203716

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.