ArticleEpidemiology and psychiatric sciences2019
Depressive symptoms and sleep problems as risk factors for heart disease: a prospective community study.
Article in Epidemiology and psychiatric sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Association between insomnia and the incidence of myocardial infarction: A systematic review and meta-analysis.Clinical cardiology · 2023Pooled it
- Joint trajectories of sleep duration and depressive symptoms and risk of incident multimorbidity: a longitudinal analysis with machine learning prediction.BMC geriatrics · 2026Article
- The Bidirectional Relationship Between Myocardial Infarction and Depression: Risk Factors, Mechanisms, and Interventions.Biomedicines · 2025Review
- Association Between Depression and the Short Sleep Duration on Weekdays and Weekends in South Korean Adults: A Cross-Sectional Study Using the 2016 and 2018 Korea National Health and Nutrition Examination Survey.Healthcare (Basel, Switzerland) · 2025Article
- The Role of Neuroinflammation in the Comorbidity of Psychiatric Disorders and Internal Diseases.Healthcare (Basel, Switzerland) · 2025Review
- Mediating Effect of Illness Perception on the Relationship Between Perceived Family Function and Sleep Quality Among Patients With Atrial Fibrillation.Nursing open · 2024Observational
- Sleep and risk of hip fracture and falls among middle-aged and older Chinese.Scientific reports · 2024Article
- Eight-year total, cognitive-affective, and somatic depressive symptoms trajectories and risks of cardiac events.Translational psychiatry · 2024Article
- Sleep and mental health among Chinese adolescents: the chain-mediating role of physical health perception and school adjustment.BMC psychology · 2024Article
- Association of sleep duration and physical frailty with cognitive function in older patients with coexisting atrial fibrillation and heart failure.Nursing open · 2023Article
- Interaction effects between sleep disorders and depression on heart failure.BMC cardiovascular disorders · 2023Article
- Use of benzodiazepine and Z-drugs and mortality in older adults after myocardial infarction.International journal of geriatric psychiatry · 2023Article
- Impact of depression on the quality of sleep and immune functions in patients with coronary artery disease.General psychiatry · 2022Article
- Cardiac glycosaminoglycans and structural alterations during chronic stress-induced depression-like behavior in mice.American journal of physiology. Heart and circulatory physiology · 2021Article
- Resilience as the Mediating Factor in the Relationship Between Sleep Disturbance and Post-stroke Depression of Stroke Patients in China: A Structural Equation Modeling Analysis.Frontiers in psychiatry · 2021Article
- Association of Sleep Duration With Atrial Fibrillation and Heart Failure: A Mendelian Randomization Analysis.Frontiers in genetics · 2021Article
- Estimating Public Knowledge About Cognitive Behavioral Therapy for Insomnia (CBT-I) and Alternative Treatments.Behavioral sleep medicineArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe goals of the present study were to examine the associations between depressive symptoms, sleep problems and the risk of developing heart disease in a Canadian community sample.
methodsBaseline data were from the CARTaGENE study, a community health survey of adults aged 40-69 years in Quebec, Canada. Incidence of heart disease was examined in N = 33 455 participants by linking survey data with administrative health insurance data. Incident heart disease was identified using the World Health Organization's International Classification of Diseases, 9th or 10th edition (ICD-9 and ICD-10) diagnostic codes for heart disease. Sleep problems were assessed with diagnostic codes for sleep disorders within the 2 years preceding the baseline assessment. Average sleep duration was assessed by self-report. Depressive symptoms were assessed with the nine-item Patient Health Questionnaire.
resultsIn total, 2448 (7.3%) participants developed heart disease over an average follow-up period of 4.6 years. Compared to those without depressive symptoms and with no sleep disorders, those with elevated depressive symptoms and a sleep disorder (HR = 2.60, 95% CI 1.83-3.69), those with depressive symptoms alone (HR = 1.40, 95% CI 1.25-1.57) and those with sleep disorders alone (HR = 1.33, 95% CI 1.03-1.73) were more likely to develop heart disease. Test of additive interaction suggested a synergistic interaction between depressive symptoms and sleep disorders (synergy index = 2.17 [95% CI 1.01-4.64]). When sleep duration was considered, those with long sleep duration and elevated depressive symptoms were more likely to develop heart disease than those with long sleep alone (HR = 1.77, 95% CI 1.37-2.28; and HR = 1.16, 95% CI 0.99-1.36, respectively).
conclusionsDepression and diagnosed sleep disorders or long sleep duration are independent risk factors for heart disease and are associated with a stronger risk of heart disease when occurring together.
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