ArticleParasites & vectors2019
Characterization of the BspA and Pmp protein family of trichomonads.
Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 62 citations in OpenAlex.
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- An Evolutionarily Conserved Laterally Acquired Toolkit Enables Microbiota Targeting by Trichomonas.Molecular biology and evolution · 2025Article
- Chromatin accessibility and gene expression in the parasite Trichomonas vaginalis.BMC infectious diseases · 2025Article
- Evolution and ecology of commensal gut protists: recent advances.Current opinion in genetics & development · 2025Review
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- Transcriptome and Evolutionary Analysis of Pseudotrichomonas keilini, a Free-Living Anaerobic Eukaryote.Genome biology and evolution · 2024Article
- Morphological and molecular characterization of parabasilids isolated from ex situ nonhuman primates and their keepers at different institutions in Brazil.International journal for parasitology. Parasites and wildlife · 2024Article
- Comparative membrane proteomic analysis of Tritrichomonas foetus isolates.Scientific reports · 2024Article
- The retromer and retriever systems are conserved and differentially expanded in parabasalids.Journal of cell science · 2024Article
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- Comparative microbiome analysis in cystic fibrosis and non-cystic fibrosis bronchiectasis.Respiratory research · 2024Article
- Comparative genomics betweenFrontiers in microbiology · 2024Article
- Sequence, structure prediction, and epitope analysis of the polymorphic membrane protein family in Chlamydia trachomatis.PloS one · 2024Article
- Unraveling the pathogenic potential of the Pentatrichomonas hominis PHGD strain: impact on IPEC-J2 cell growth, adhesion, and gene expression.Parasite (Paris, France) · 2024Article
- PIP2 regulating calcium signal modulates actin cytoskeleton-dependent cytoadherence and cytolytic capacity in the protozoan parasite Trichomonas vaginalis.PLoS pathogens · 2023Article
- The divergent ER-mitochondria encounter structures (ERMES) are conserved in parabasalids but lost in several anaerobic lineages with hydrogenosomes.BMC biology · 2023Article
- Unusual structural and functional features of TpLRR/BspA-like LRR proteins.Journal of structural biology · 2023Review
- Revisiting fecal metatranscriptomics analyses of macaques with idiopathic chronic diarrhoea with a focus on trichomonad parasites.Parasitology · 2023Article
- Evolutionary conservation ofFrontiers in microbiology · 2023Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundTrichomonas vaginalis is a human-infecting trichomonad and as such the best studied and the only for which the full genome sequence is available considering its parasitic lifestyle, T. vaginalis encodes an unusually high number of proteins. Many gene families are massively expanded and some genes are speculated to have been acquired from prokaryotic sources. Among the latter are two gene families that harbour domains which share similarity with proteins of Bacteroidales/Spirochaetales and Chlamydiales: the BspA and the Pmp proteins, respectively.
resultsWe sequenced the transcriptomes of five trichomonad species and screened for the presence of BspA and Pmp domain-containing proteins and characterized individual candidate proteins from both families in T. vaginalis. Here, we demonstrate that (i) BspA and Pmp domain-containing proteins are universal to trichomonads, but specifically expanded in T. vaginalis; (ii) in line with a concurrent expansion of the endocytic machinery, there is a high number of BspA and Pmp proteins which carry C-terminal endocytic motifs; and (iii) both families traffic through the ER and have the ability to increase adhesion performance in a non-virulent T. vaginalis strain and Tetratrichomonas gallinarum by a so far unknown mechanism.
conclusionsOur results initiate the functional characterization of these two broadly distributed protein families and help to better understand the origin and evolution of BspA and Pmp domains in trichomonads.
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