ArticleActa neuropathologica communications2019
Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations.
Open access · goldAbstract readComparative Study
In one paragraph
Article in Acta neuropathologica communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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35citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- A Systematic Review of MicroRNAs in Hemorrhagic Neurovascular Disease: Cerebral Cavernous Malformations as a Paradigm.International journal of molecular sciences · 2025Pooled it
- Cerebral cavernous malformations: epidemiology, molecular pathogenesis, diagnosis and therapy.Molecular biomedicine · 2026Review
- MicroRNA-21-3p regulation of NADPH oxidase 4 and vascular endothelial growth factor A contributes to hemorrhage in cerebral cavernous malformations.Non-coding RNA research · 2026Article
- The Role of Immune Infiltration and Oxidative Stress in the Progression of Cerebral Cavernous Malformation.Brain and behavior · 2026Review
- Integration of artificial intelligence and high-content screening enabled identification of drugs for long-term treatment of cerebral cavernous malformation disease.bioRxiv : the preprint server for biology · 2025Article
- Common and distinct circulating microRNAs in four neurovascular disorders.Biochemistry and biophysics reports · 2025Article
- Except for Robust Outliers, Rapamycin Increases Lesion Burden in a Murine Model of Cerebral Cavernous Malformations.Translational stroke research · 2025Article
- Molecular mechanisms of CAND2 in regulating SCF ubiquitin ligases.Nature communications · 2025Article
- Single-cell transcriptome profiling reveals dynamic cell populations and immune infiltration in cerebral cavernous malformation.Frontiers in immunology · 2025Article
- Review
- Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation.Nature cardiovascular research · 2024Article
- TLNRD1 is a CCM complex component and regulates endothelial barrier integrity.The Journal of cell biology · 2024Article
- Transcriptomic signatures of individual cell types in cerebral cavernous malformation.Cell communication and signaling : CCS · 2024Article
- Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain.Nature medicine · 2023Article
- Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation.Brain sciences · 2023Review
- Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease.Translational stroke research · 2023Article
- Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma.Communications medicine · 2023Article
- Endothelial Differentiation ofInternational journal of molecular sciences · 2023Article
- A feasibility study for quantitative assessment of cerebrovascular malformations using flutriciclamide ([Frontiers in medicine · 2023Article
- Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformation Disease.Circulation research · 2022Article
Corrections and comments
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Authors and funding
29 authors at 4 institutions in 1 country.
Janne KoskimäkiNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Dongdong ZhangNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Yan LiCenter for Research Informatics, The University of Chicago, Chicago, IL, USA.
Laleh SaadatNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Thomas MooreNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Rhonda LightleNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Sean P PolsterNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Julián Carrión-PenagosNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Seán B LyneNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Hussein A ZeineddineNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Changbin ShiNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Robert ShenkarNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.ORCID 0000-0002-1300-6845
Sharbel RomanosNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Kenneth AvnerNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Abhinav SrinathNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Le ShenNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Matthew R DetterThe Molecular Genetics and Microbiology Department, Duke University Medical Center, Durham, NC, USA.
Daniel SnellingsThe Molecular Genetics and Microbiology Department, Duke University Medical Center, Durham, NC, USA.
Ying CaoNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Miguel A Lopez-RamirezDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Gregory FonsecaDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Alan T TangDepartment of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.
Pieter FaberUniversity of Chicago Genomics Facility, The University of Chicago, Chicago, IL, USA.
Jorge AndradeCenter for Research Informatics, The University of Chicago, Chicago, IL, USA.
Mark GinsbergDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Mark L KahnDepartment of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.
Douglas A MarchukThe Molecular Genetics and Microbiology Department, Duke University Medical Center, Durham, NC, USA.
Romuald GirardNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Issam A AwadNeurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA. iawad@uchicago.edu.
University of Chicago · USDuke Medical Center · USUniversity of California San Diego · USUniversity of Pennsylvania · US
Funding
VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI MARK W. LINGEN · 1985 to 2026
$122.1MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2MHEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAMT32HL007439 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE F BRASS, PETER S KLEIN · 1985 to 2026
$17.1MSomatic mutation(s) and cellular changes in CCM pathogenesisP01NS092521 · NINDS · DUKE UNIVERSITY · PI KAHN, MARK L · 2015 to 2024
$12.9MTraining In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1MHeg-CCM Signaling in Cardiovascular Development and DiseaseR01HL094326 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAHN, MARK L · 2009 to 2018
$3.5MUCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3MTLR4 and the microbiome in CCM diseaseR01NS100949 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KAHN, MARK L · 2017 to 2021
$2.8MInvestigating the Molecular Pathways of Cerebral Cavernous Malformation MaturationF30HL140871 · NHLBI · DUKE UNIVERSITY · PI DETTER, MATTHEW ROBERT · 2018 to 2021
$91kThe molecular pathogenesis of cerebral cavernous malformationsF30NS100252 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TANG, ALAN TIEN · 2017 to 2018
$80kNCI NIH HHS P30 CA014599NHLBI NIH HHS F30 HL140871NHLBI NIH HHS R01 HL094326NHLBI NIH HHS R25 HL145817NHLBI NIH HHS T32 HL007439NHLBI NIH HHS T32 HL007444NIGMS NIH HHS T32 GM007171NIH HHS F30 HL140871NIH HHS P30 CA14599NIH HHS T32 GM007171NINDS NIH HHS F30 NS100252NINDS NIH HHS P01 NS092521NINDS NIH HHS R01 NS100949
Abstract
Cerebral cavernous malformations (CCMs) are dilated capillaries causing epilepsy and stroke. Inheritance of a heterozygous mutation in CCM3/PDCD10 is responsible for the most aggressive familial form of the disease. Here we studied the differences and commonalities between the transcriptomes of microdissected lesional neurovascular units (NVUs) from acute and chronic in vivo Ccm3/Pdcd10
Indexed as
Disease ProgressionAnimalsApoptosis Regulatory ProteinsCentral Nervous System NeoplasmsGene Regulatory NetworksHemangioma, Cavernous, Central Nervous SystemMiceMice, Inbred C57BLMice, TransgenicTranscriptomeApoptosis Regulatory ProteinsPDCD10 protein, mouseCavernous angiomaCcm3Cerebral cavernous malformationHemangiomamiRNAMouse modelTranscriptome
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