ArticleTrials2019
Clinical trial data reuse - overcoming complexities in trial design and data sharing.
Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Enhanced Health Study Discoverability: Graph-Based Analysis Approach.JMIR medical informatics · 2026Article
- TrialR: critical enablers and the need for reusable Rare Disease Clinical Trial infrastructure in Western Australia.Orphanet journal of rare diseases · 2026Article
- Open challenges for the automatic synthesis of clinical trials.BMC research notes · 2025Article
- Article
- FDA Oncology Center of Excellence Crowdsourcing Initiative: Outreach to the Scientific Community to Identify Research Questions for Pooled Analyses of Oncology Clinical Trial Data.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Article
- Inhibition of Interleukin-17 in Patients with Oligoarticular Psoriatic Arthritis.Rheumatology and therapy · 2023Article
- Synthetic Data Generation by Artificial Intelligence to Accelerate Research and Precision Medicine in Hematology.JCO clinical cancer informatics · 2023Article
- Investigating the Secondary Use of Clinical Research Data: Protocol for a Mixed Methods Study.JMIR research protocols · 2023Article
- Discoverability of information on clinical trial data-sharing platforms.Journal of the Medical Library Association : JMLA · 2021Article
- Data Sharing Goals for Nonprofit Funders of Clinical Trials.Journal of participatory medicine · 2021Article
- CONSIDER Statement: Consolidated Recommendations for Sharing Individual Participant Data from Human Clinical Studies.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational ScienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
There are many acknowledged benefits for the reuse of clinical trial data; from independent verification of published results to the evaluation of new hypotheses. However, the reuse of shared clinical trial data is not without obstacles. Here we present some of the issues and lessons learned from our own experiences in accessing and analyzing trial data; specifically, where we aim to combine and pool data from multiple different trials. In addition to issues around missing annotation and incomplete datasets, we identify trial-design complexity as a potential hurdle that may complicate downstream analyses. We address potential solutions and emphasize the need for benefits of transparent sharing and analysis of participant-level clinical trial data with appropriate risk mitigation, a matter important to efficient clinical research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.