ArticleBMC health services research2019
Hospital and economic burden of influenza-like illness and lower respiratory tract infection in adults ≥50 years-old.
Article in BMC health services research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Characteristics of influenza, SARS-CoV-2, and RSV surveillance systems that utilise ICD-coded data: a systematic review.Journal of global health · 2025Pooled it
- Management cost of acute respiratory infections in older adults in China: A systematic review and meta-analysis.Journal of global health · 2024Pooled it
- The economic burden of influenza among adults aged 18 to 64: A systematic literature review.Influenza and other respiratory viruses · 2022Pooled it
- Trial
- Disparities in the potentially avoidable use of emergency services by citizenship: a two-year cross-sectional study in Italy.BMC public health · 2026Article
- Utilising unsupervised machine learning to predict outbreaks of respiratory tract infections in acute Irish hospitals (2016-2021).Public health in practice (Oxford, England) · 2026Article
- How much do lower respiratory tract infections in adults cost? A hospital-based cost analysis in Colombia.Cost effectiveness and resource allocation : C/E · 2026Article
- Estimating the economic burden of lower respiratory infections in China from 2020 to 2040: a health-augmented macroeconomic modelling study.The Lancet regional health. Western Pacific · 2026Article
- Analysis of an AI-powered system for vaccination screening, monitoring, and management in adults aged 50 and above.Frontiers in public health · 2026Article
- Cost-Effectiveness Analysis of the High-Dose Trivalent Influenza Vaccine in the Elderly Population in Italy.ClinicoEconomics and outcomes research : CEOR · 2026Article
- Navigating Vaccine Misinformation: Assessing Newly Licensed Physicians' Ability to Distinguish Facts from Fake News.Epidemiologia (Basel, Switzerland) · 2025Article
- Article
- Article
- Evaluation of CLINITEST® Rapid Covid-19 + Influenza antigen test in a cohort of symptomatic patients in an emergency department.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Excess hospitalizations and in-hospital mortality associated with seasonal influenza in Italy: a 11-year retrospective study.BMC infectious diseases · 2024Article
- Rates of Lower Respiratory Tract Illness in US Adults by Age and Comorbidity Profile.Infectious diseases and therapy · 2024Article
- Enhanced passive safety surveillance of the MF59-adjuvanted quadrivalent influenza vaccine in the elderly during the 2021/22 influenza season.Human vaccines & immunotherapeutics · 2023Article
- The burden of influenza and the role of influenza vaccination in adults aged 50-64 years: A summary of available evidence.Human vaccines & immunotherapeutics · 2023Review
- Cost-effectiveness for high dose quadrivalent versus the adjuvanted quadrivalent influenza vaccine in the Italian older adult population.Frontiers in public health · 2023Article
- Economic burden of pneumococcal disease in children in Liguria, Italy.Human vaccines & immunotherapeutics · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfluenza-like illnesses (ILIs) and lower respiratory tract infections (LRTIs) cause substantial morbidity and mortality worldwide. The study assessed the health and economic burden of ILI and LRTI according to age and comorbidities, since available evidence is limited and heterogeneous.
methodThe prevalence of comorbidities, the seasonal incidence rates and the mean and per capita direct costs of ED accesses for ILI/LRTI, whether followed by hospitalization or not, recorded in adults aged ≥50 years over the last 6 years, in the referral hospitals located in the Genoese metropolitan area (Liguria, Italy) where the syndromic surveillance system is active, were evaluated through a retrospective observational study. Comorbidities were estimated through the Chronic Condition Data Warehouse that integrates multiple Medicare data sources. A comparison with the administrative healthcare International Classification of Diseases-9th revision-Clinical Modification (ICD-9-CM)-based data was also conducted.
resultsThe prevalence of subjects with ≥1 comorbidity ranged from 23.49 to 59.92%. The most prevalent all-age comorbidities were cardiovascular diseases and cancer. The overall ILI/LRTI incidence rate was 6.73/1000 person-years, almost double the value derived from routine data, and increased with age. The highest rates were observed in patients with renal failure and bronchopneumopathies. The mean cost of ED accesses/hospitalization for ILI/LRTI was €3353 and was almost twice as high in the ≥85 years as in the youngest age-group. The highest mean costs were observed in patients with renal failure and cancer. The per capita costs increased from €4 to €71 with age, and were highest in patients with renal failure and bronchopneumopathy.
conclusionThe burden of ILIs/LRTIs in terms of ED accesses and hospitalizations in adults aged ≥50 years is heavy, and is related to increasing age and, especially, to specific comorbidities. These results could contribute to revising age- and risk-based anti-influenza and -pneumococcus immunization strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.