Evidence map›Paper›PMID 31426790›Full record

ArticleBMC veterinary research2019

Veterinary pharmacovigilance in sub-Sahara Africa context: a pilot study of adverse reactions to veterinary medicine in Cameroon.

Mohamed Moctar Mouliom Mouiche, Badou Zaki Ndouoya Njingou, Frédéric Moffo, Serge Eugene Mpouam, Jean Marc Kameni Feussom, Julius Awah-Ndukum

Open access · goldAbstract read
In one paragraph

Article in BMC veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

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  11. Effect of topical dermatologic medications in humans on household pets.Proceedings (Baylor University. Medical Center) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Mohamed Moctar Mouliom MouicheDepartment of Pharmacy, Pharmacology and Toxicology, School of Veterinary Medicine and Sciences, University of Ngaoundere, Ngaoundere, Cameroon. mouichemoctar4@gmail.com.ORCID http://orcid.org/0000-0002-4900-3670
Badou Zaki Ndouoya NjingouDepartment of Pharmacy, Pharmacology and Toxicology, School of Veterinary Medicine and Sciences, University of Ngaoundere, Ngaoundere, Cameroon.
Frédéric MoffoDepartment of Pharmacy, Pharmacology and Toxicology, School of Veterinary Medicine and Sciences, University of Ngaoundere, Ngaoundere, Cameroon.
Serge Eugene MpouamDepartment of Pharmacy, Pharmacology and Toxicology, School of Veterinary Medicine and Sciences, University of Ngaoundere, Ngaoundere, Cameroon.
Jean Marc Kameni FeussomCameroon Epidemiological Network for Animal Diseases (RESCAM), Directorate of Veterinary Services, Ministry of Livestock, Fisheries and Animal Industries (MINEPIA), Yaoundé, Cameroon.
Julius Awah-NdukumDepartment of Pharmacy, Pharmacology and Toxicology, School of Veterinary Medicine and Sciences, University of Ngaoundere, Ngaoundere, Cameroon.
University of Ngaoundéré · CMMinistry of Livestock, Fisheries and Animal Industries · CMMinistry of Public Health · CMUniversity of Bamenda · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSub-Saharan African market is highly affected by counterfeit veterinary drugs. Though these counterfeit and non-compliance of drugs can induce adverse effects during their utilization, there is no monitoring system of veterinary medicines. The present pilot study was carried out in Cameroon to identify and describe suspected cases of adverse reactions to veterinary drugs in animals and / or humans as well as inefficacy of veterinary drugs. The methodology involved a descriptive cross-sectional survey of 67 actors in the veterinary medicine sector in Cameroon.

resultsA total of 74/120 (62%) cases of suspected adverse effects and or lack of efficacy of veterinary drugs in animals and 46 (38%) cases of adverse reactions in humans were identified. Antiparasitics were the most incriminated therapeutic class in animals (61%) and human (56%). Adverse reactions were reported in dogs (44%) and poultry (24%) while drug inefficacy was most observed in poultry (47%). According to animal health professionals, levamisole (24%) and ivermectin (16%) were identified to be responsible for the adverse effects and that the highest level of inefficacy was most frequently reported for oxytetracycline (29%). The main adverse reactions were systemic (22%), gastrointestinal (20%) and neurological (13%) disorders.

conclusionThe results of this study showed that misuse and circulation of poor quality as well as lack of efficacy of veterinary drugs is very common in Cameroon. Adverse reactions were observed in animals and humans. Therefore, the establishment of a national veterinary pharmacovigilance system based on solid legal bases is essential for a continuous assessment of the risks-benefits effects of veterinary drugs marketed in Cameroon.

Indexed as

Africa South of the SaharaAnimal DiseasesAnimalsCameroonCounterfeit DrugsCross-Sectional StudiesData CollectionLegislation, DrugPilot ProjectsVeterinary DrugsCounterfeit DrugsVeterinary DrugsAdverse drugs reactionsCameroonInefficacyPharmacovigilanceReportingVeterinary medicine

Identifiers

PMID31426790
PMCPMC6701137
OpenAlexW2969529494

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.