Evidence map›Paper›PMID 31426664›Full record

ReviewCell transplantation

Interspecies Organogenesis for Human Transplantation.

Andrew T Crane, Rajagopal N Aravalli, Atsushi Asakura, Andrew W Grande, Venkatramana D Krishna, Daniel F Carlson, Maxim C-J Cheeran, Georgette Danczyk, James R Dutton, Perry B Hackett and 16 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. International journal of stem cells · 2022
    Review
  7. Article
  8. Review
  9. Article
  10. Induction and Maturation of Hepatocyte-Like CellsFrontiers in cell and developmental biology · 2021
    Review
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 2 institutions in 1 country.

Andrew T CraneDepartment of Neurosurgery, University of Minnesota, Minneapolis, USA.
Rajagopal N AravalliDepartment of Electrical and Computer Engineering, University of Minnesota, Minneapolis, USA.
Atsushi AsakuraStem Cell Institute, University of Minnesota, Minneapolis, USA.
Andrew W GrandeDepartment of Neurosurgery, University of Minnesota, Minneapolis, USA.
Venkatramana D KrishnaDepartment of Veterinary Population Medicine, University of Minnesota, St. Paul, USA.
Daniel F CarlsonRecombinetics, Inc., St. Paul, USA.
Maxim C-J CheeranDepartment of Veterinary Population Medicine, University of Minnesota, St. Paul, USA.ORCID 0000-0002-5331-4746
Georgette DanczykDepartment of Neurosurgery, University of Minnesota, Minneapolis, USA.
James R DuttonStem Cell Institute, University of Minnesota, Minneapolis, USA.
Perry B HackettDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, USA.
Wei-Shou HuDepartment of Chemical Engineering and Material Science, University of Minnesota, Minneapolis, USA.
Ling LiDepartment of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, USA.
Wei-Cheng LuDepartment of Neurosurgery, University of Minnesota, Minneapolis, USA.
Zachary D MillerDepartment of Neurosurgery, University of Minnesota, Minneapolis, USA.ORCID 0000-0003-1064-1234
Timothy D O'BrienStem Cell Institute, University of Minnesota, Minneapolis, USA.
Angela Panoskaltsis-MortariDepartment of Pediatrics, University of Minnesota, Minneapolis, USA.
Ann M ParrDepartment of Neurosurgery, University of Minnesota, Minneapolis, USA.
Clairice PearceDepartment of Neurosurgery, University of Minnesota, Minneapolis, USA.
Mercedes Ruiz-EstevezDepartment of Neurosurgery, University of Minnesota, Minneapolis, USA.
Maple ShiaoDepartment of Neurosurgery, University of Minnesota, Minneapolis, USA.
Christopher J SipeDepartment of Neurosurgery, University of Minnesota, Minneapolis, USA.
Nikolas G TomanDepartment of Neurosurgery, University of Minnesota, Minneapolis, USA.
Joseph VothDepartment of Neurosurgery, University of Minnesota, Minneapolis, USA.
Hui XieDepartment of Neurosurgery, University of Minnesota, Minneapolis, USA.
Clifford J SteerStem Cell Institute, University of Minnesota, Minneapolis, USA.
Walter C LowDepartment of Neurosurgery, University of Minnesota, Minneapolis, USA.
University of Minnesota · USRecombinetics (United States) · US

Funding

Generating Exogenic Hippocampal Neural Cells via Blastocyst Complementation for Transplantation in Alzheimer's Disease.R01DK117286 · NIDDK · UNIVERSITY OF MINNESOTA · PI STEER, CLIFFORD JOHN · 2018 to 2021
$2.4M
NIDDK NIH HHS R01 DK117286
6 · The paper itself

Abstract

Blastocyst complementation combined with gene editing is an emerging approach in the field of regenerative medicine that could potentially solve the worldwide problem of organ shortages for transplantation. In theory, blastocyst complementation can generate fully functional human organs or tissues, grown within genetically engineered livestock animals. Targeted deletion of a specific gene(s) using gene editing to cause deficiencies in organ development can open a niche for human stem cells to occupy, thus generating human tissues. Within this review, we will focus on the pancreas, liver, heart, kidney, lung, and skeletal muscle, as well as cells of the immune and nervous systems. Within each of these organ systems, we identify and discuss (i) the common causes of organ failure; (ii) the current state of regenerative therapies; and (iii) the candidate genes to knockout and enable specific exogenous organ development via the use of blastocyst complementation. We also highlight some of the current barriers limiting the success of blastocyst complementation.

Indexed as

Animals, Genetically ModifiedGene Expression Regulation, DevelopmentalOrganogenesisOrgan TransplantationPluripotent Stem CellsAnimalsBlastocystHumansblastocyst complementationdevelopmentgene editingorgan bioengineeringtransplantation

Identifiers

PMID31426664
PMCPMC6767879
OpenAlexW2969996347

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.