ArticleJournal of fungi (Basel, Switzerland)2019
Diagnosis of Progressive Disseminated Histoplasmosis in Advanced HIV: A Meta-Analysis of Assay Analytical Performance.
Article in Journal of fungi (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Systematic Review of Prevalence of Histoplasma Antigenuria in Persons with HIV in Latin America and Africa.Emerging infectious diseases · 2024Pooled it
- Article
- Histoplasmosis: a missing piece in the global efforts to end HIV deaths.The lancet. HIV · 2026Review
- Histoplasma antigen detection: A laboratory-based retrospective review of routine testing from 2021 to 2023.Biomedica : revista del Instituto Nacional de Salud · 2026Article
- Unusual gastrointestinal histoplasmosis with jejunal perforation in a 57-year-old patient from Bogotá: Case report.Biomedica : revista del Instituto Nacional de Salud · 2026Article
- Article
- The Molecular Diagnosis of Invasive Fungal Diseases with a Focus on PCR.Diagnostics (Basel, Switzerland) · 2025Review
- Large language models and their performance for the diagnosis of histoplasmosis.PLoS neglected tropical diseases · 2025Article
- Development of a Diagnostic Score for Histoplasmosis in a Cohort of Patients With HIV.Open forum infectious diseases · 2025Article
- Histoplasmosis in Immunocompromised and Immunocompetent Patients in Guadeloupe.Journal of fungi (Basel, Switzerland) · 2025Article
- Usefulness of Serum as a Non-Invasive Sample for the Detection ofJournal of fungi (Basel, Switzerland) · 2025Article
- Practical Guidance for Clinical Microbiology Laboratories: Antibody and antigen detection methods for dimorphic fungal infections.Clinical microbiology reviews · 2025Review
- Photo Quiz: A cutaneous fungal infection with discordant biomarker results-a diagnostic challenge.Journal of clinical microbiology · 2025Article
- High Genetic Diversity of Histoplasma in the Amazon Basin, 2006-2017.Emerging infectious diseases · 2025Article
- Evolving Epidemiology, Improving Diagnostic Tests and Their Importance for the Correct Diagnosis of Histoplasmosis.Journal of fungi (Basel, Switzerland) · 2025Review
- Histoplasmosis.Infectious disease clinics of North America · 2025Review
- Implementation of Antigen-Based Diagnostic Assays for Detection of Histoplasmosis and Cryptococcosis among Patients with Advanced HIV in Trinidad and Tobago: A Cross-Sectional Study.Journal of fungi (Basel, Switzerland) · 2024Article
- Disseminated histoplasmosis diagnosed on a blood smear in a Nigerian patient with non-Hodgkin's lymphoma.Oxford medical case reports · 2024Article
- Disseminated histoplasmosis with skin manifestations in advanced HIV: Case report.Revista medica del Instituto Mexicano del Seguro Social · 2024Article
- Disseminated histoplasmosis in an HIV/AIDS transgender male-to-female with atypical and persistent GI manifestations.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histoplasmosis is an important cause of mortality in people with advanced HIV, especially in countries with limited access to diagnostic assays. Histoplasmosis can be diagnosed using culture, histopathology, and antibody, antigen, and molecular assays. Several factors may affect the analytical performance of these laboratory assays, including sample type, clinical stage of the disease, and previous use of antifungal treatment, among others. Here we describe the results of a systematic literature review, followed by a meta-analysis of the analytical performances of the diagnostic laboratory assays employed. Our initial search identified 1631 references, of which 1559 references were excluded after title and abstract screening, leaving 72 references identified as studies relevant to the validation of histoplasmosis diagnostic assays. After evaluating the full text, 30 studies were selected for final review, including one paper not identified in the initial search. The meta-analysis for assay analytical performance shows the following results for the overall sensitivity (Sen) and specificity (Spe) of the various methods evaluated: Culture, Sen 77% (no data for specificity calculation); antibody detection assays, Sen 58%/Spe 100%; antigen detection assays, Sen 95%/Spe 97%; and DNA detection assays (molecular), Sen 95%/Spe 99%. Of the 30 studies reviewed, nearly half (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.