Evidence map›Paper›PMID 31426593›Full record

ReviewNutrients2019

The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity.

Manuel A González Hernández, Emanuel E Canfora, Johan W E Jocken, Ellen E Blaak

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 303 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
303citing papers in PubMed, 9 pooled it
30.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

303 citing papers in PubMed, 9 syntheses or guidelines pooled it, 594 citations in OpenAlex.

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  5. New Mediators in the Crosstalk between Different Adipose Tissues.International journal of molecular sciences · 2024
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  18. Microorganisms · 2026
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243 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Manuel A González HernándezDepartment of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Universiteitssingel 50, P.O. Box 616, 6229 ER Maastricht, The Netherlands.
Emanuel E CanforaDepartment of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Universiteitssingel 50, P.O. Box 616, 6229 ER Maastricht, The Netherlands.
Johan W E JockenDepartment of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Universiteitssingel 50, P.O. Box 616, 6229 ER Maastricht, The Netherlands.
Ellen E BlaakDepartment of Human Biology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Universiteitssingel 50, P.O. Box 616, 6229 ER Maastricht, The Netherlands. e.blaak@maastrichtuniversity.nl.
Maastricht University Medical Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interplay of gut microbiota, host metabolism, and metabolic health has gained increased attention. Gut microbiota may play a regulatory role in gastrointestinal health, substrate metabolism, and peripheral tissues including adipose tissue, skeletal muscle, liver, and pancreas via its metabolites short-chain fatty acids (SCFA). Animal and human data demonstrated that, in particular, acetate beneficially affects host energy and substrate metabolism via secretion of the gut hormones like glucagon-like peptide-1 and peptide YY, which, thereby, affects appetite, via a reduction in whole-body lipolysis, systemic pro-inflammatory cytokine levels, and via an increase in energy expenditure and fat oxidation. Thus, potential therapies to increase gut microbial fermentation and acetate production have been under vigorous scientific scrutiny. In this review, the relevance of the colonically and systemically most abundant SCFA acetate and its effects on the previously mentioned tissues will be discussed in relation to body weight control and glucose homeostasis. We discuss in detail the differential effects of oral acetate administration (vinegar intake), colonic acetate infusions, acetogenic fiber, and acetogenic probiotic administrations as approaches to combat obesity and comorbidities. Notably, human data are scarce, which highlights the necessity for further human research to investigate acetate's role in host physiology, metabolic, and cardiovascular health.

Indexed as

Gastrointestinal MicrobiomeInsulin ResistanceAcetic AcidAnimalsAppetiteBlood GlucoseBody WeightColonCytokinesDietary FiberEnergy MetabolismFatty Acids, VolatileGastrointestinal HormonesHumansInsulinLipid MetabolismAcetic AcidBlood GlucoseCytokinesDietary FiberFatty Acids, VolatileGastrointestinal HormonesInsulinacetatedietary fibermicrobiotaobesitytype 2 diabetes

Identifiers

PMID31426593
PMCPMC6723943
OpenAlexW2968634018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.